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首页> 外文期刊>Hormones and behavior >Early life stress effects on adult stress-induced corticosterone secretion and anxiety-like behavior in the C57BL/6 mouse are not as robust as initially thought.
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Early life stress effects on adult stress-induced corticosterone secretion and anxiety-like behavior in the C57BL/6 mouse are not as robust as initially thought.

机译：早期生活应激对C57BL / 6小鼠的成年应激诱导的皮质酮分泌和焦虑样行为的影响并不像最初想象的那样强大。

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Understanding environmental effects on mouse brain development would allow us to take advantage of powerful genetic tools to determine the interaction between genetic and epigenetic factors governing brain development in C57BL/6 mice. Experiment 1 examined whether time of day for neonatal manipulations affects adult stress-induced hormone secretion. Three rearing groups were examined: early handled (EH; dam removed 10 min/day); maternal separated (MS; dam removed 180 min/day); and an animal facility raised (AFR) control. Separations occurred during either the first or last 3 h of the light phase. Corticosterone (CORT) secretion in response to 100 dB white noise was assessed in adulthood. Both EH and MS males separated during the last 3 h of the light phase exhibited blunted stress-induced CORT compared to all other groups. Experiment 2 varied time of behavior testing. A fourth group was also added: maternal isolated (MI; separated from dam and littermates 180 min/day). Adult male behavior was assessed in three different tests. EH males tested in the elevated zero maze (EZM) during the light phase and MS males tested in the EZM during the dark phase exhibited diminished anxiety-like behavior compared to the other groups. We conclude that the EH protocol is marginally effective in blunting stress-induced CORT secretion and anxiety-like behavior in C57BL/6 mice, and these early handling effects are influenced by time of day. We also conclude that the 3 h MS or MI protocol is not effective in exacerbating future adult stress-induced CORT secretion or anxiety-like behavior in C57BL/6 mice.
机译：了解环境对小鼠大脑发育的影响将使我们能够利用强大的遗传工具来确定控制C57BL / 6小鼠大脑发育的遗传和表观遗传因素之间的相互作用。实验1检验了一天中的新生儿操作时间是否会影响成人压力诱发的激素分泌。检查了三个饲养组：早期处理（EH;大坝拆除10分钟/天）;产妇分居（MS;水坝拆除180分钟/天）;以及动物饲养设施（AFR）的控制。在光照阶段的前3小时或后3小时发生分离。在成年期评估了响应100 dB白噪声的皮质酮（CORT）分泌。与所有其他组相比，在光相的最后3小时内分离的EH和MS雄性均表现出钝化的应激诱导CORT。实验2进行行为测试的时间不同。还增加了第四组：母体隔离（MI;与大坝和同窝仔隔离180分钟/天）。成年男性行为通过三种不同的测试进行了评估。与其他组相比，在浅色阶段在高零位迷宫（EZM）中测试的EH雄性和在黑暗阶段在EZM中测试的MS雄性表现出减少的焦虑样行为。我们得出的结论是，EH协议在使C57BL / 6小鼠的应激诱导的CORT分泌减弱和焦虑样行为方面略显有效，并且这些早期处理效果受一天中的时间影响。我们还得出结论，3小时MS或MI协议在加重C57BL / 6小鼠未来成年应激诱导的CORT分泌或焦虑样行为方面无效。

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