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首页> 外文期刊>Hormones and behavior >The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats
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The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats

机译：长期服用皮质酮对低焦虑和高焦虑大鼠脑结构焦虑和抑郁样行为及GABA-A受体α-2亚基表达的影响

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The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration. The animals were divided into LR and HR groups based on the duration of their conditioned freezing in a contextual fear test. Repeated daily administration of corticosterone (20. mg/kg) for 21. days decreased activity in a forced swim test, reduced body weight and decreased prefrontal cortex corticosterone concentration in both the LR and HR groups. These effects of corticosterone administration were stronger in the HR group in comparison with the appropriate control group, and compared to LR treated and LR control animals. Moreover, in the HR group, chronic corticosterone administration increased anxiety-like behavior in the open field and elevated plus maze tests. The behavioral effects in HR rats were accompanied by a decrease in alpha-2 subunit density in the medial prefrontal cortex (prelimbic cortex and frontal association cortex) and by an increase in the expression of alpha-2 subunits in the basolateral amygdala. These studies have shown that HR rats are more susceptible to anxiogenic and depressive effects of chronic corticosterone administration, which are associated with modification of GABA-A receptor function in the medial prefrontal cortex and basolateral amygdala. The current data may help to better understand the neurobiological mechanisms responsible for individual differences in changes in mood and emotions induced by repeated administration of high doses of glucocorticoids or by elevated levels of these hormones associated with chronic stress or affective pathology.
机译：这项研究的目的是检查大鼠情绪行为的变化，并确定反复服用皮质酮后低（LR）和高焦虑（HR）大鼠脑结构中GABA-A受体α-2亚基表达的差异。根据情境恐惧测试中条件性冻结的持续时间，将动物分为LR和HR组。在LR和HR组中，每天重复服用皮质酮（20. mg / kg）21天，在强迫游泳试验中活动减少，体重减轻和前额叶皮质皮质酮浓度降低。与适当的对照组相比，与LR治疗的动物和LR对照动物相比，HR组皮质激素的这些作用更强。此外，在HR组中，长期服用皮质类固醇可增加在旷野的焦虑样行为，并增加迷宫测试。 HR大鼠的行为效应伴随着内侧前额叶皮层（前缘皮层和额叶缔合皮层）中α-2亚基密度的降低以及基底外侧杏仁核中α-2亚基的表达增加。这些研究表明，HR大鼠更容易受到长期服用皮质酮的焦虑和抑郁作用，这与内侧额前皮层和基底外侧杏仁核中GABA-A受体功能的改变有关。当前数据可能有助于更好地理解神经生物学机制，这些机制是由于反复服用高剂量糖皮质激素或这些激素水平升高（与慢性应激或情感病理相关）而引起的情绪和情感变化个体差异的原因。

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