New clues about vitamin D functions in the nervous system.

Garcion E; Wion Barbot N; Montero Menei CN; Berger F; Wion D

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New clues about vitamin D functions in the nervous system.

机译：有关维生素D在神经系统中起作用的新线索。

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Accumulating data have provided evidence that 1 alpha,25 dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] is involved in brain function. Thus, the nuclear receptor for 1,25-(OH)(2)D(3) has been localized in neurons and glial cells. Genes encoding the enzymes involved in the metabolism of this hormone are also expressed in brain cells. The reported biological effects of 1,25-(OH)(2)D(3) in the nervous system include the biosynthesis of neurotrophic factors and at least one enzyme involved in neurotransmitter synthesis. 1,25-(OH)(2)D(3) can also inhibit the synthesis of inducible nitric oxide synthase and increase glutathione levels, suggesting a role for the hormone in brain detoxification pathways. Neuroprotective and immunomodulatory effects of this hormone have been described in several experimental models, indicating the potential value of 1,25-(OH)(2)D(3) pharmacological analogs in neurodegenerative and neuroimmune diseases. In addition, 1,25-(OH)(2)D(3) induces glioma cell death, making the hormone of potential interest in the management of brain tumors. These results reveal previously unsuspected roles for 1,25-(OH)(2)D(3) in brain function and suggest possible areas of future research.

机译：越来越多的数据提供了证据，表明1 alpha，25 dihydroxyvitamin D（3）[1,25-（OH）（2）D（3）]与脑功能有关。因此，1,25-（OH）（2）D（3）的核受体已被定位在神经元和神经胶质细胞中。编码参与这种激素代谢的酶的基因也在脑细胞中表达。 1,25-（OH）（2）D（3）在神经系统中的生物学作用包括生物合成神经营养因子和至少一种参与神经递质合成的酶。 1,25-（OH）（2）D（3）还可以抑制诱导型一氧化氮合酶的合成并增加谷胱甘肽水平，表明该激素在脑排毒途径中的作用。此激素的神经保护和免疫调节作用已在几个实验模型中进行了描述，表明1,25-（OH）（2）D（3）药理类似物在神经退行性疾病和神经免疫疾病中具有潜在价值。此外，1,25-（OH）（2）D（3）诱导神经胶质瘤细胞死亡，使激素在脑肿瘤的治疗中具有潜在的意义。这些结果揭示了1,25-（OH）（2）D（3）在脑功能中的先前未曾想到的作用，并暗示了未来研究的可能领域。

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《Trends in Endocrinology and Metabolism: TEM》 |2002年第3期|共6页
作者
Garcion E; Wion Barbot N; Montero Menei CN; Berger F; Wion D;
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正文语种 eng
中图分类基础医学;
关键词
Calcitriol; Nervous System; 骨化三醇; 神经系统;

机译：Calcitriol;Nervous System;骨化三醇;神经系统;

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New clues about vitamin D functions in the nervous system.

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