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首页> 外文期刊>Trends in Endocrinology and Metabolism: TEM >Regulation of cholesterol supply for mineralocorticoid biosynthesis.
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Regulation of cholesterol supply for mineralocorticoid biosynthesis.

机译：调节盐皮质激素生物合成的胆固醇供应。

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摘要

In addition to intracellular cholesterol synthesis, plasma low- and high-density lipoproteins (LDL and HDL, respectively) are the major potential sources of a cholesterol precursor for steroid synthesis in all steroidogenic tissues. LDL- and HDL-cholesterol are taken up by cells through entirely distinct mechanisms. In the case of aldosterone production in the zona glomerulosa of the adrenal cortex, it has been assumed in the past that LDL is the major supplier of cholesterol. However, recent developments, in particular the discovery of the scavenger receptor class B type I for HDL and the characterization of its properties, have questioned this view. In fact, the nature of the challenging factor (angiotensin II or adrenocorticotropic hormone) appears to determine which pool of cholesterol is preferentially mobilized and which pathway (LDL receptor endocytosis or selective uptake through the HDL receptor) is regulated.
机译：除细胞内胆固醇合成外，血浆低密度和高密度脂蛋白（分别为LDL和HDL）是所有类固醇生成组织中类固醇合成的胆固醇前体的主要潜在来源。细胞通过完全不同的机制吸收LDL和HDL胆固醇。在肾上腺皮质的肾小球带中产生醛固酮的情况下，过去认为LDL是胆固醇的主要供应商。然而，最近的发展，特别是对于HDL的I类清道夫受体B型的发现及其性质的表征，对该观点提出了质疑。实际上，挑战性因子（血管紧张素II或促肾上腺皮质激素）的性质似乎决定了优先动员哪个胆固醇库和哪个通路（LDL受体内吞作用或通过HDL受体的选择性摄取）受到调节。

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