Gene interactions in depression: pathways out of darkness

Harvey M; Belleau P; Barden N

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Gene interactions in depression: pathways out of darkness

机译：抑郁症中的基因相互作用：走出黑暗的途径

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Mood disorders, including major depressive disorder and bipolar disorder, are influenced by both genetic and environmental factors. Hypotheses about the neurobiology of mood disorders have been postulated and putatively associated genes identified. Recently, the immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder. New candidate genes and emerging gene networks and pathways involved in the aetiology of mood disorders point to a major role for neuronal survival and the adaptive immune systems.

机译：情绪障碍，包括重度抑郁症和躁郁症，受遗传和环境因素的影响。关于情绪障碍的神经生物学的假设已被假定，并推定了相关的基因。最近，编码嘌呤能受体P2X，配体门控离子通道7（P2RX7）的免疫相关基因在遗传上与主要的抑郁症和双相情感障碍有关。情绪障碍的病因学中涉及的新候选基因和新兴基因网络及途径指出了神经元存活和适应性免疫系统的重要作用。

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《Trends in Genetics》 |2007年第11期|共10页
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Harvey M; Belleau P; Barden N;
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正文语种 eng
中图分类遗传学;
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1. Gene interactions in depression: pathways out of darkness [J] . Harvey M, Belleau P, Barden N Trends in Genetics . 2007,第11期

机译：抑郁症中的基因相互作用：走出黑暗的途径
2. Escitalopram affects cytoskeleton and synaptic plasticity pathways in a rat gene–environment interaction model of depression as revealed by proteomics. Part II: environmental challenge [J] . Chiara Piubelli, Miriam Vighini, Aleksander A. Mathé, The International Journal of Neuropsychopharmacology . 2011,第6期

机译：如蛋白质组学所揭示的，依西酞普兰影响抑郁症大鼠基因-环境相互作用模型中的细胞骨架和突触可塑性途径。第二部分：环境挑战
3. Escitalopram affects cytoskeleton and synaptic plasticity pathways in a rat gene–environment interaction model of depression as revealed by proteomics. Part II: environmental challenge [J] . Aleksander A. Mathé, Chiara Piubelli, Enrico Domenici, The international journal of neuropsychopharmacology . 2011,第6期

机译：如蛋白质组学所揭示的，依西酞普兰影响抑郁症的大鼠基因-环境相互作用模型中的细胞骨架和突触可塑性途径。第二部分：环境挑战
4. Novel Optical Generation of Ultrawideband (UWB) Signals Using Quadratic Nonlinear Interactions Seeded By Normal/Dark Pulses [C] . Jian Wang, Qizhen Sun, Junqiang Sun European Conference on Optical Communication . 2009

机译：采用正常/暗脉冲播种的二次非线性相互作用的二次非线性相互作用的新型光学产生
5. Reverse engineering of gene regulatory networks for discovery of novel interactions in pathways using gene expression data. [D] . Habib, Tanwir. 2009

机译：基因调控网络的逆向工程，可利用基因表达数据发现途径中的新型相互作用。
6. Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF-κB Signaling Pathway [O] . Francisco J. Monje, Maureen Cabatic, Isabella Divisch, 2011

机译：恒定的黑暗通过NF-κB信号通路诱导IL-6依赖性的抑郁样行为
7. Escitalopram affects cytoskeleton and synaptic plasticity pathways in a rat gene–environment interaction model of depression as revealed by proteomics. Part II: environmental challenge [O] . Chiara Piubelli, Miriam Vighini, Aleksander A. Mathé, 2011

机译：EscitalOpram影响了蛋白质组学揭示的大鼠基因 - 环境相互作用模型中的细胞骨架和突触塑性途径。第二部分：环境挑战

Gene interactions in depression: pathways out of darkness

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