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Is pigment patterning in fish skin determined by the Turing mechanism?

机译:鱼皮中的色素图案是否由图灵机制决定?

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More than half a century ago, Alan Turing postulated that pigment patterns may arise from a mechanism that could be mathematically modeled based on the diffusion of two substances that interact with each other. Over the past 15 years, the molecular and genetic took to verify this prediction have become available. Here, we review experimental studies aimed at identifying the mechanism underlying pigment pattern formation in zebrafish. Extensive molecular genetic studies in this model organism have revealed the interactions between the pigment cells that are responsible for the patterns. The mechanism discovered is substantially different from that predicted by the mathematical model, but it retains the property of 'local activation and long-range inhibition', a necessary condition for Turing pattern formation. Although some of the molecular details of pattern formation remain to be elucidated, current evidence confirms that the underlying mechanism is mathematically equivalent to the Turing mechanism.
机译:半个多世纪以前,阿兰·图灵(Alan Turing)推测,颜料图案可能来自一种机制,该机制可以基于相互作用的两种物质的扩散进行数学建模。在过去的15年中,用于验证这一预测的分子和遗传学已经变得可用。在这里,我们回顾旨在确定斑马鱼中的色素图案形成机理的实验研究。在这种模式生物中的广泛分子遗传学研究揭示了负责模式的色素细胞之间的相互作用。发现的机理与数学模型所预测的机理有很大的不同,但是它保留了“局部激活和远距离抑制”的特性,这是形成图灵图案的必要条件。尽管仍然需要阐明一些有关分子形成的分子细节,但目前的证据证实,其潜在机理在数学上等同于图灵机理。

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