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首页> 外文期刊>Trends in Genetics >Revisiting classic clines in Drosophila melanogaster in the age of genomics
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Revisiting classic clines in Drosophila melanogaster in the age of genomics

机译：在基因组学时代重温果蝇中的经典血统

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摘要

Adaptation to spatially varying environments has been studied for decades, but advances in sequencing technology are now enabling researchers to investigate the landscape of genetic variation underlying this adaptation genome wide. In this review we highlight some of the decades-long research on local adaptation in Drosophila melanogaster from well-studied clines in North America and Australia. We explore the evidence for parallel adaptation and identify commonalities in the genes responding to clinal selection across continents as well as discussing instances where patterns differ among clines. We also investigate recent studies utilizing whole-genome data to identify clines in D. melanogaster and several other systems. Although connecting segregating genomic variation to variation in phenotypes and fitness remains challenging, clinal genomics is poised to increase our understanding of local adaptation and the selective pressures that drive the extensive phenotypic diversity observed in nature.
机译：适应空间变化环境的研究已经进行了数十年，但是测序技术的进步现在使研究人员能够研究整个适应基因组的遗传变异情况。在这篇综述中，我们重点介绍了来自北美和澳大利亚的经过深入研究的果蝇对果蝇果蝇局部适应的数十年研究。我们探索了平行适应的证据，并确定了响应大洲的滨海选择的基因的共性，并讨论了种系间模式不同的实例。我们还调查了最近的研究，该研究利用全基因组数据来鉴定D. melanogaster和其他几个系统中的系。尽管将分离的基因组变异与表型和适应性变异联系起来仍然具有挑战性，但临床基因组有望增加我们对局部适应性和驱动自然界中广泛表型多样性的选择性压力的理解。

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