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V2R gene families degenerated in primates, dog and cow, but expanded in opossum

机译:V2R基因家族在灵长类,狗和牛中退化,但在负鼠中扩展

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The V2R genes are expressed in the mammalian vomeronasal organ, and their products are involved in detecting pheromones. Here, we describe the evolution of the V2R gene family. We have found that the human, chimpanzee, macaque, cow and dog V2R gene families have completely degenerated. Each now contains 9-20 pseudogenes but no intact V2R genes. By contrast, opossum has approximately 90 intact V2R genes that mostly arose by duplication after opossum and rodent lineages diverged. One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined.
机译:V2R基因在哺乳动物的犁鼻器器官中表达,其产物参与信息素的检测。在这里,我们描述了V2R基因家族的进化。我们发现人类,黑猩猩,猕猴,牛和狗的V2R基因家族已完全退化。现在每个都包含9-20个假基因,但没有完整的V2R基因。相比之下,负鼠具有大约90个完整的V2R基因,大部分是由负鼠和啮齿动物谱系分化后重复产生的。一个具有异常生物学特性的V2R基因亚家族非典型地进化,显示出啮齿类动物的扩展有限,并且在所有其他物种中,单个的直系同源物(有时有时功能失调)的持续存在。

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