Nuclear insertions of organellar DNA can create novel patches of functional exon sequences

Noutsos C; Kleine T; Armbruster U; DalCorso G; Leister D

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Nuclear insertions of organellar DNA can create novel patches of functional exon sequences

机译：细胞核DNA的核插入可以创建功能性外显子序列的新片段

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Recent nuclear transfer of organellar DNA is thought to result mainly in nonfunctional nuclear sequences or in genetic dysfunction. Here we show that nuclear exons encoding novel protein sequences can be generated by insertions of organellar DNA. Most of the protein sequences do not correspond to preexisting organellar coding sequences or they represent markedly reshaped protein domains, reflecting the recruitment and adaptation of encoded proteins to new functions. Organelle-derived DNA insertions might be responsible for many more ancient functional exon acquisitions that are not directly detectable.

机译：据认为，最近的细胞器DNA的核转移主要导致无功能的核序列或遗传功能障碍。在这里，我们显示了编码新蛋白序列的核外显子可以通过插入细胞器DNA来生成。大多数蛋白质序列不对应于先前存在的细胞器编码序列，或者它们代表着显着重塑的蛋白质结构域，反映了编码蛋白的募集和适应新功能。细胞器衍生的DNA插入可能是许多无法直接检测到的更古老的功能性外显子获取的原因。

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《Trends in Genetics》 |2007年第12期|共5页
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Noutsos C; Kleine T; Armbruster U; DalCorso G; Leister D;
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正文语种 eng
中图分类遗传学;
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1. Nuclear insertions of organellar DNA can create novel patches of functional exon sequences [J] . Noutsos C, Kleine T, Armbruster U, Trends in Genetics . 2007,第12期

机译：细胞核DNA的核插入可以创建功能性外显子序列的新片段
2. Concordant Genetic Distinctness of the Phylogroup of the Siberian Chipmunk from the Korean Peninsula (Tamias sibiricus barberi), Reexamined with Nuclear DNA c-myc Gene Exon 2 and mtDNA Control Region Sequences [J] . Hung Sun Koh, Minghai Zhang, Damdingiin Bayarlkhagva, Biochemical Genetics . 2010,第s7a8期

机译：用核DNA c-myc基因外显子2和mtDNA控制区序列重新检查了朝鲜半岛（Tamias sibiricus barberi）西伯利亚花栗鼠的Phylogroup的一致遗传差异。
3. No evidence of non-homologous insertions in mouse model of MDD created by replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence. [J] . Zubenko GS, Hughes HB 3rd American journal of medical genetics, Part B. Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics . 2012,第1期

机译：没有证据表明用致病性6-碱基人CREB1启动子序列替换同源小鼠DNA序列可在MDD小鼠模型中产生非同源插入。
4. Performance analysis of window functions for exon prediction in DNA sequences [C] . Sanyogita Sharma, Kanika Sandal, Pardeep Garg, International Conference on Computing, Communication and Automation . 2017

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6. Plant Organellar DNA Polymerases Evolved Multifunctionality through the Acquisition of Novel Amino Acid Insertions [O] . Antolín Peralta-Castro, Paola L. García-Medel, Noe Baruch-Torres, 2020

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7. UNDERSTANDING EVOLUTIONARY RELATIONSHIPS IN THE ANGIOSPERM ORDER APIALES BASED ON ANALYSES OF ORGANELLAR DNA SEQUENCES AND NUCLEAR GENE DUPLICATIONS [O] . Nicolas Antoine 2009

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Nuclear insertions of organellar DNA can create novel patches of functional exon sequences

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