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首页> 外文期刊>Human Immunology: Official Journal of the American Society for Histocompatibility and Immunogenetics >HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí's volunteer bone marrow donors enrolled at the Brazilian registry
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HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí's volunteer bone marrow donors enrolled at the Brazilian registry

机译：在巴西登记处登记的Piauí志愿者骨髓供体中的HLA-A，HLA-B和HLA-DRB1单倍型频率

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摘要

This study aimed to report the antigen and haplotype frequencies (HFs) of volunteer bone marrow donors (VBMDs) from the state of Piauí who were enrolled in the National Volunteer Bone Marrow Donor Registry (REDOME). The research subjects were 21,943 volunteer bone marrow donors, predominantly young adult women (53.3%). The most frequent allelic group was HLA-A2, followed by -DRB1*13, -DRB1*04, -DRB1*07, -B*15, -B*35, -B*44, -A*24 and -A*03.Of the 2,704 haplotypes observed, the three most frequent haplotypes were A*29 B*44 DRB1*07 (1.45%), A*01 B*08 DRB1*03 (1.4%) and A *03 B*07 DRB1*15 (0.92%). These three haplotypes were in linkage disequilibrium. PCA showed that 98% of the VBMDs have HLA allele frequencies that are very similar to those from Teresina, the capital city of Piauí. According to the PCA results, these municipalities are distributed with a close proximity to Teresina, which in turn has a close genetic proximity to the Hispanic ethnicity, intermediate proximity to Caucasians and Africans and a distant kinship to Amerindians. The hierarchical proximity of the population of Piauí to the Portuguese and Hispanic populations to shows the strong influence of the latter on the former.
机译：这项研究旨在报告来自皮奥伊州的自愿骨髓捐献者（VBMD）的抗原和单倍型频率（HFB），这些人已被纳入国家志愿者骨髓捐献者登记册（REDOME）。研究对象为21,943名志愿者骨髓捐献者，主要是年轻成年女性（53.3％）。最常见的等位基因组是HLA-A2，其次是-DRB1 * 13，-DRB1 * 04，-DRB1 * 07，-B * 15，-B * 35，-B * 44，-A * 24和-A * 03.在观察到的2704个单元型中，三个最常见的单元型为A * 29 B * 44 DRB1 * 07（1.45％），A * 01 B * 08 DRB1 * 03（1.4％）和A * 03 B * 07 DRB1 * 15（0.92％）。这三种单倍型处于连锁不平衡状态。 PCA显示98％的VBMD的HLA等位基因频率与首都Piauí的Teresina的频率非常相似。根据PCA的结果，这些直辖市的分布与特雷西纳（Teresina）十分接近，而特雷西纳（Teresina）与西班牙裔的遗传距离非常近，与高加索人和非洲人的距离非常近，与美洲印第安人的血缘也很远。皮奥伊人口与葡萄牙和西班牙裔人口的等级接近程度，显示了后者对前者的强大影响。

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