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首页> 外文期刊>Human vaccines >Yersinia pestis biovar Microtus strain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques
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Yersinia pestis biovar Microtus strain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques

机译：鼠疫耶尔森菌Biotus Microtus菌株201，对人类无毒的菌株，可防止猕猴猕猴桃鼠疫

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摘要

Yersinia pestis biovar Microtus is considered to be a virulent to larger mammals, including guinea pigs, rabbits and humans. It may be used as live attenuated plague vaccine candidates in terms of its low virulence. However, the Microtus strain's protection against plague has yet to be demonstrated in larger mammals. In this study, we evaluated the protective efficacy of the Microtus strain 201 as a live attenuated plague vaccine candidate. Our results show that this strain is highly attenuated by subcutaneous route, elicits an F1 -specific antibody titer similar to the EV and provides a protective efficacy similar to the EV against bubonic plague in Chinese-origin rhesus macaques. The Microtus strain 201 could induce elevated secretion of both Th1 -associated cytokines (IFN-gamma, IL-2 and TNF-alpha) and Th2-associated cytokines (IL-4, IL-5, and IL-6), as well as chemokines MCP-1 and IL-8. However, the protected animals developed skin ulcer at challenge site with different severity in most of the immunized and some of the EV-immunized monkeys. Generally, the Microtus strain 201 represented a good plague vaccine candidate based on its ability to generate strong humoral and cell-mediated immune responses as well as its good protection against high dose of subcutaneous virulent Y. pestis challenge.
机译：鼠疫耶尔森菌的微生物田鼠被认为对包括豚鼠，兔子和人类在内的较大的哺乳动物具有毒性。就其低毒力而言，它可用作减毒鼠疫活疫苗的候选者。然而，在大型哺乳动物中尚未证明Microtus菌株对鼠疫的保护作用。在这项研究中，我们评估了Microtus菌株201作为减毒鼠疫活疫苗的防护效果。我们的结果表明，该菌株通过皮下途径高度减毒，引起类似于EV的F1特异性抗体滴度，并提供与EV相似的针对中华猕猴猕猴鼠鼠疫的保护功效。 Microtus菌株201可以诱导Th1相关细胞因子（IFN-γ，IL-2和TNF-α）和Th2相关细胞因子（IL-4，IL-5和IL-6）以及两者的分泌增加趋化因子MCP-1和IL-8。但是，受保护的动物在大多数免疫接种的猴子和某些EV免疫接种的猴子中，在攻击部位出现了严重程度不同的皮肤溃疡。通常，基于其产生强烈的体液和细胞介导的免疫应答的能力以及针对高剂量的皮下有毒力的鼠疫耶尔森氏菌攻击的良好保护作用，田鼠属（Microtus）菌株201是很好的瘟疫疫苗候选者。

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