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Perinatal hepatitis B prevention program in Shandong Province, China Evaluation and progress

机译:中国山东省围产期乙肝预防计划的评估和进展

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Perinatal transmission of hepatitis B virus (HBV) from mothers to infants is a major source of chronic HBV infection. ' Post-exposure prophylaxis (PEP) with hepatitis B vaccine (HepB) is 70-95% effective in preventing perinatal HBV transmission among infants born to mothers who are hepatitis B surface antigen (HBsAg) positive and hepatitis B e antigen positive ; while HepB and Hepatitis B immune globulin (HBIG) at birth, followed by 2 to 3 additional doses of HepB, is 85-95% effective.3"5 Studies in areas highly endemic for HBV have shown that passive-active PEP with HBIG and HepB more effectively prevents perinatal HBV transmission than HepB alone. "8 The World Health Organization (WHO) recommends universal HepB as soon as possible after birth, preferably within 24 h regardless of maternal HBsAg status, even in countries with low-endemicity.
机译:乙型肝炎病毒(HBV)从母亲向婴儿的围产期传播是慢性HBV感染的主要来源。乙型肝炎疫苗(HepB)的暴露后预防(PEP)在预防乙型肝炎表面抗原(HBsAg)阳性和乙型肝炎e抗原阳性的母亲所生婴儿中的围产期HBV传播有效率为70-95%;而出生时的HepB和B型肝炎免疫球蛋白(HBIG)以及随后的2至3剂量的HepB有效率为85-95%。3“ 5在HBV高度流行的地区进行的研究表明,HBIG和与仅使用HepB相比,HepB更有效地防止了围产期HBV传播。“ 8世界卫生组织(WHO)建议,无论出生的HBsAg状况如何,即使在低流行国家,也应尽早在出生后24h内普遍使用HepB。

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