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HIV-1 vaccine design: harnessing diverse lymphocytes to conquer a diverse pathogen.

机译:HIV-1疫苗设计:利用多种淋巴细胞征服多种病原体。

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摘要

In the fall of 2007, the HIV-1 research field received news that their front-runner vaccine was not protective. In response to this disappointment, scientists are now reviewing the intricacies of the immune response toward HIV-1 to develop new and better strategies for vaccine development. Decades ago, researchers recognized the impressive amino acid and carbohydrate diversity of HIV-1, and the associated obstacles to vaccine development. At first glance, the diversity and other unique features of HIV-1 may seem insurmountable, but attention to vaccine successes in other fields serves to renew optimism. The newly-licensed rotavirus and papillomavirus cocktail vaccines remind scientists that diverse pathogens can be conquered and that the chronic nature of a virus infection need not thwart successful vaccine design. Here we describe current efforts to gain insights from other vaccine fields and to adopt a cocktail vaccine approach for the prevention of HIV-1 infections in humans.
机译:在2007年秋天,HIV-1研究领域收到了有关他们的领先疫苗没有保护作用的消息。针对这种失望,科学家现在正在审查针对HIV-1的免疫反应的复杂性,以开发新的更好的疫苗开发策略。几十年前,研究人员认识到HIV-1令人印象深刻的氨基酸和碳水化合物多样性以及疫苗开发的相关障碍。乍一看,HIV-1的多样性和其他独特特征似乎不可逾越,但关注其他领域疫苗的成功有助于人们重新乐观。新获得许可的轮状病毒和乳头瘤病毒鸡尾酒疫苗提醒科学家,可以攻克各种病原体,并且病毒感染的慢性性质不必妨碍成功的疫苗设计。在这里,我们描述了当前从其他疫苗领域获得见识并采用鸡尾酒疫苗方法预防人类HIV-1感染的努力。

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