M?ssbauer and X-ray study of biodegradation of ~(57)Fe _3O_4 magnetic nanoparticles in rat brain

R. R. Gabbasov; V. M. Cherepanov; M. A. Chuev; A. A. Lomov; I. N. Mischenko; M. P. Nikitin; M. A. Polikarpov; V. Y. Panchenko

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M?ssbauer and X-ray study of biodegradation of ~(57)Fe _3O_4 magnetic nanoparticles in rat brain

机译：M？ssbauer和X射线研究大鼠脑中〜（57）Fe _3O_4磁性纳米粒子的生物降解

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Biodegradation of a ~(57)Fe _3O_4 - based dextran - stabilized ferrofluid in the ventricular cavities of the rat brain was studied by X-ray diffraction and M?ssbauer spectroscopy. A two-step process of biodegradation, consisting of fast disintegration of the initial composite magnetic beads into separate superparamagnetic nanoparticles and subsequent slow dissolution of the nanoparticles has been found. Joint fitting of the couples of M?ssbauer spectra measured at different temperatures in the formalism of multi-level relaxation model with one set of fitting parameters, allowed us to measure concentration of exogenous iron in the rat brain as a function of time after the injection of nanoparticles.

机译：通过X射线衍射和Msssbauer光谱研究了〜（57）Fe _3O_4基右旋糖酐稳定的铁磁流体在大鼠脑室腔中的降解。已发现生物降解的两步过程，包括将初始复合磁珠快速分解成单独的超顺磁性纳米颗粒，以及随后缓慢溶解纳米颗粒。在多级弛豫模型的形式上用一组拟合参数联合拟合在不同温度下测量的M？ssbauer光谱对，这使我们能够测量注射后随时间变化的大鼠脑中外源铁的浓度纳米粒子。

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《Hyperfine Interactions: Journal Devoted to Research in the Border Regions of Solid State, Atomic and Nuclear Physics》 |2016年第1期|共12页
作者
R. R. Gabbasov; V. M. Cherepanov; M. A. Chuev; A. A. Lomov; I. N. Mischenko; M. P. Nikitin; M. A. Polikarpov; V. Y. Panchenko;
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正文语种 eng
中图分类固体物理学;分子物理学、原子物理学;原子核物理学、高能物理学;
关键词
M?ssbauer spectroscopy; X-ray diffraction; Superparamagnetic nanoparticles; Brain; Biodegradation;

机译：Mssbauer光谱;X射线衍射;超顺磁性纳米粒子;脑;生物降解;

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3. M?ssbauer and X-ray study of biodegradation of ~(57)Fe _3O_4 magnetic nanoparticles in rat brain [J] . R. R. Gabbasov, V. M. Cherepanov, M. A. Chuev, Hyperfine Interactions: Journal Devoted to Research in the Border Regions of Solid State, Atomic and Nuclear Physics . 2016,第1期

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5. Biodegradation of Magnetic Nanoparticles in Rat Brain Studied by Mössbauer Spectroscopy [J] . Polikarpov D. M., Gabbasov R. R., Cherepanov V. M., Magnetics, IEEE Transactions on . 2013,第1期

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M?ssbauer and X-ray study of biodegradation of ~(57)Fe _3O_4 magnetic nanoparticles in rat brain

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