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首页> 外文期刊>Hypertension research: Official journal of the Japanese Society of Hypertension >T allele of -344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension.
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T allele of -344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension.

机译：醛固酮合酶基因中-344C / T多态性的T等位基因与耐药性高血压无关。

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Resistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.Hypertension Research (2009) 32, 159-162; doi:10.1038/hr.2008.36; published online 23 January 2009.
机译：抵抗性高血压（RH）是维持血压升高并同时使用三种不同的抗高血压药，其中一种是利尿药。肾素-血管紧张素-醛固酮系统在体积依赖性高血压中起主要作用。因此，其组成是遗传关联研究的有趣目标。这项工作集中于CYP11b2基因的-344 C / T多态性，该基因编码醛固酮合酶。这项工作评估T等位基因与抗高血压治疗的抵抗性之间的关联。基因分型分析包括88位RH受试者，142位对降压治疗有反应的受试者和110位受试者作为对照组。在较小部分的高血压患者中评估了醛固酮，肾素和皮质醇的血浆浓度，颈动脉内膜中层厚度和颈动脉股动脉脉搏波速度。 T等位基因与高血压之间存在关联（P <0.005），但两组高血压之间的等位基因频率无差异。基因型组之间的血浆指标和重塑指标也没有差异。HypertensionResearch（2009）32，159-162; doi：10.1038 / hr.2008.36; 2009年1月23日在线发布。

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