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首页> 外文期刊>Hypertension in pregnancy: Official journal of the International Society for the Study of Hypertension in Pregnancy >In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study.
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In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study.

机译：先兆子痫的体外血浆诱导的内皮细胞氧化应激和内皮功能障碍的循环标志物：一项观察性研究。

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OBJECTIVE: To investigate plasma-induced endothelial reactive oxygen species (ROS) production in vitro and its relation to endothelial dysfunction in preeclampsia (PE). METHODS: Plasma was drawn from 17 PE patients, 17 matched healthy pregnant (HP) women, 17 matched non-pregnant healthy volunteers (NP), and 10 septic shock (SC) patients. In vitro plasma-induced ROS production was assessed in cultured human endothelial cells. In vivo endothelial activation and injury were assessed through measurements of plasma von Willebrand factor (vWF) and soluble thrombomodulin (sTM) concentrations, respectively. RESULTS: Endothelial ROS production was not induced by PE, HP, and NP plasmas. However, it was significantly increased in SC compared to other groups (p < .005). Pregnancy (PE and HP) was associated with higher vWF compared to NP. Among pregnancies, vWF was higher in PE compared to HP women (p < .05). sTM was unchanged between PE, HP and NP. In SC, vWF and sTM were significantly increased compared to other groups (p < .01). Simultaneously, endothelial ROS production and sTM concentration were correlated (p = .673; p < .05). CONCLUSION. Plasma does not induce in vitro endothelial ROS production in PE women for which endothelial dysfunction is limited to activation but not injury. By contrast, SC patients demonstrate both endothelial activation and injury, closely related to plasma-induced endothelial oxidative stress.
机译：目的：探讨子痫前期（PE）血浆诱导的血管内皮活性氧（ROS）的产生及其与内皮功能障碍的关系。方法：从17名PE患者，17名健康孕妇（HP），17名健康孕妇（NP）和10名败血性休克（SC）患者中抽取血浆。在培养的人内皮细胞中评估了体外血浆诱导的ROS产生。通过分别测量血浆von Willebrand因子（vWF）和可溶性血栓调节蛋白（sTM）浓度来评估体内内皮的激活和损伤。结果：PE，HP和NP血浆未诱导内皮ROS的产生。但是，与其他组相比，SC中的SC显着增加（p <.005）。与NP相比，妊娠（PE和HP）与较高的vWF相关。在妊娠中，PE中的vWF高于HP女性（p <.05）。 PE，HP和NP之间的sTM没有变化。与其他组相比，SC中的vWF和sTM显着增加（p <.01）。同时，内皮ROS的产生与sTM浓度相关（p = .673; p <.05）。结论。在内皮功能障碍仅限于激活而不是损伤的PE妇女中，血浆不会诱导体外内皮ROS的产生。相比之下，SC患者表现出内皮激活和损伤，与血浆诱导的内皮氧化应激密切相关。

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