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首页> 外文期刊>Hypertension research: Official journal of the Japanese Society of Hypertension >Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats.
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Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats.

机译：普罗布考不能延长易发盐的中风自发性高血压大鼠的生存。

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摘要

We examined the effect of probucol, a lipid-lowering agent with strong antioxidant properties, on neurological events and survival in stroke-prone spontaneously hypertensive rats (SHRSP). Rapid onset of stroke was induced by maintaining the animals on 1% NaCl solution in place of drinking water. Probucol (10 or 30 mg/kg/day), both of which doses are therapeutic in humans was given by gastric gavage once daily to salt-loaded SHRSP. Animals receiving vehicle were used as controls. Probucol did not influence the elevation of blood pressure. Although probucol did not improve the survival rate of salt-loaded SHRSP, 30 mg/ kg/day of probucol slightly but significantly delayed the development of neurological events (p=0.0235 by generalized Wilcoxon test). However, a high dose of probucol (100 mg/kg/day) did not change the survival or neurological events of salt-loaded SHRSP. These results suggest that probucol may be protective against the development of neurological events, but is not preventive for the progression of stroke in SHRSP.
机译：我们检查了中风倾向性自发性高血压大鼠（SHRSP）中具有强抗氧化特性的降脂剂普罗布考对神经系统事件和存活的影响。通过将动物维持在1％NaCl溶液中代替饮用水来诱导中风的快速发作。普罗布考（10或30 mg / kg /天），这两种剂量都对人体有效，每天通过一次胃管灌胃给予盐载SHRSP。接受媒介物的动物用作对照。普罗布考不影响血压升高。尽管普罗布考不能提高盐负荷SHRSP的存活率，但30毫克/千克/天的普罗布考略有提高，但显着延迟了神经系统事件的发生（根据广义Wilcoxon试验，p = 0.0235）。但是，高剂量的普罗布考（100 mg / kg /天）并没有改变盐负荷SHRSP的存活或神经系统事件。这些结果表明，普罗布考可能对神经系统事件的发展具有保护作用，但不能预防SHRSP中风的进展。

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