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首页> 外文期刊>Hypertension research: Official journal of the Japanese Society of Hypertension >Plasma endothelin-1 levels and circulating endothelial cells in patients with aortoarteritis.
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Plasma endothelin-1 levels and circulating endothelial cells in patients with aortoarteritis.

机译:主动脉炎患者血浆内皮素-1水平和循环内皮细胞水平。

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摘要

To investigate the correlation between plasma endothelin-1 (ET-1), circulating endothelial cells (CECs), and the disease activity in patients with aortoarteritis. In this study, radioimmunoassay was used to measure plasma levels of ET-1 in 56 patients with aortoarteritis. Circulating endothelial cell counts were also carried out as an indicator of vessel wall lesions. The plasma levels of ET-1 and CECs in the active disease patient group were significantly higher than those in inactive patient group (p<0.001). A significant positive correlation was found between plasma ET-1 levels and erythrocyte sedimentation rates (ESRs) in patients with aortoarteritis (r=0.645, p<0.001), as well as CECs (r=0.876, p<0.001). These results suggested that the ET-1 secreted during the active stages of aortoarteritis may cause constriction and proliferation of vascular smooth muscle cells, thus contributing to the pathogenesis of luminal narrowing. The increased CECs might serve as a marker of disease activity.
机译:研究血浆内皮素-1(ET-1),循环内皮细胞(CEC)与主动脉炎患者疾病活动之间的相关性。在这项研究中,放射免疫分析法用于测量56例主动脉炎患者的血浆ET-1水平。还进行了循环内皮细胞计数,作为血管壁病变的指标。活动疾病患者组的血浆ET-1和CECs明显高于非活动患者组(p <0.001)。在主动脉炎患者(r = 0.645,p <0.001)和CECs(r = 0.876,p <0.001)中,血浆ET-1水平与红细胞沉降率(ESRs)之间存在显着正相关。这些结果表明,在主动脉炎活动期分泌的ET-1可能引起血管平滑肌细胞的收缩和增殖,从而导致管腔狭窄的发病机理。 CEC的增加可能是疾病活动的标志。

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