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首页> 外文期刊>Hypertension research: Official journal of the Japanese Society of Hypertension >Vascular remodeling of the carotid artery in patients with untreated essential hypertension increases with age.
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Vascular remodeling of the carotid artery in patients with untreated essential hypertension increases with age.

机译：未经治疗的原发性高血压患者的颈动脉血管重构随年龄增长而增加。

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We examined whether hypertrophy of the carotid artery in patients with untreated essential hypertension is associated with compensatory carotid artery enlargement as these patients age. Carotid ultrasonography was evaluated in 163 patients with untreated essential hypertension (74 males and 89 females) and in 76 normotensive subjects. Intima-media end-diastolic thickness (IMT) and outer vessel diameter (VD) were measured, and relative wall thickness (IMT/R, R=VD/2) and vascular mass (VM) were calculated. Determinants of vascular hypertrophy in patients with untreated essential hypertension were also investigated. VD, VM, and IMT were significantly correlated with age in both the normotensive and hypertensive groups. Additionally, IMT was significantly correlated with VD in both groups. There was no correlation between increasing age and IMT/R in either group. IMT, VD and VM were significantly higher in the hypertensive group >50 years than in age-matched normotensive controls. However, IMT/R was significantly higher in the 50-59 years hypertensive group than in normotensive controls of the same age group. In addition to age, VM was related to systolic blood pressure, pulse pressure, fasting blood sugar, IMT, VD, and IMT/R in the hypertensive group. Multivariate regression analysis in the hypertensive group indicated that IMT/R was the strongest predictor of carotid vascular mass. Age and pulse pressure were also independently related to vascular mass. These results indicate that, as patients with untreated hypertension age, carotid arteries undergo remodeling. This should add further impetus to the implementation of appropriate hypertension treatment for such patients.
机译：我们检查了未经治疗的原发性高血压患者中随着年龄的增长，颈动脉肥大是否与代偿性颈动脉增大有关。对163例未经治疗的原发性高血压患者（74例男性和89例女性）和76例血压正常的受试者进行了颈动脉超声检查。测量内膜中舒张末期厚度（IMT）和外血管直径（VD），并计算相对壁厚（IMT / R，R = VD / 2）和血管质量（VM）。还研究了未经治疗的原发性高血压患者血管肥大的决定因素。在正常血压组和高血压组中，VD，VM和IMT与年龄显着相关。另外，两组的IMT与VD显着相关。两组的年龄增长和IMT / R之间均无相关性。 > 50岁的高血压组的IMT，VD和VM显着高于年龄匹配的正常血压对照组。然而，在相同年龄组的正常血压对照组中，50-59岁高血压组的IMT / R明显高于正常血压组。除年龄外，高血压组的VM与收缩压，脉压，空腹血糖，IMT，VD和IMT / R有关。高血压组的多元回归分析表明，IMT / R是颈动脉血管质量的最强预测因子。年龄和脉压也与血管质量独立相关。这些结果表明，随着未经治疗的高血压患者年龄的增长，颈动脉进行重塑。这将进一步推动对此类患者进行适当的高血压治疗。

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