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首页> 外文期刊>Hypertension: An Official Journal of the American Heart Association >Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions
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Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions

机译：动态血压与尿中咖啡因和咖啡因代谢产物排泄的关系

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Intake of caffeinated beverages might be associated with reduced cardiovascular mortality possibly via the lowering of blood pressure. We estimated the association of ambulatory blood pressure with urinary caffeine and caffeine metabolites in a population-based sample. Families were randomly selected from the general population of Swiss cities. Ambulatory blood pressure monitoring was conducted using validated devices. Urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured in 24 hours urine using ultrahigh performance liquid chromatography tandem mass spectrometry. We used mixed models to explore the associations of urinary excretions with blood pressure although adjusting for major confounders. The 836 participants (48.9% men) included in this analysis had mean age of 47.8 and mean 24-hour systolic and diastolic blood pressure of 120.1 and 78.0 mm Hg. For each doubling of caffeine excretion, 24-hour and night-time systolic blood pressure decreased by 0.642 and 1.107 mm Hg (both P values <0.040). Similar inverse associations were observed for paraxanthine and theophylline. Adjusted night-time systolic blood pressure in the first (lowest), second, third, and fourth (highest) quartile of paraxanthine urinary excretions were 110.3, 107.3, 107.3, and 105.1 mm Hg, respectively (P trend <0.05). No associations of urinary excretions with diastolic blood pressure were generally found, and theobromine excretion was not associated with blood pressure. Anti-hypertensive therapy, diabetes mellitus, and alcohol consumption modify the association of caffeine urinary excretion with systolic blood pressure. Ambulatory systolic blood pressure was inversely associated with urinary excretions of caffeine and other caffeine metabolites. Our results are compatible with a potential protective effect of caffeine on blood pressure.
机译：摄入含咖啡因的饮料可能会降低血压，从而降低心血管死亡率。我们估算了基于人群的样本中动态血压与尿中咖啡因和咖啡因代谢产物的关系。从瑞士城市的总人口中随机选择家庭。动态血压监测使用经过验证的设备进行。使用超高效液相色谱串联质谱法在24小时尿液中测定尿中咖啡因，对黄嘌呤，茶碱和可可碱的排泄量。尽管调整了主要混杂因素，我们仍使用混合模型来探索尿排泄与血压之间的关系。该分析包括的836名参与者（男性48.9％）的平均年龄为47.8，平均24小时收缩压和舒张压为120.1和78.0 mm Hg。咖啡因排泄量每增加一倍，则24小时和夜间收缩压分别降低0.642和1.107 mm Hg（均P值<0.040）。对黄嘌呤和茶碱观察到相似的逆相关性。副黄嘌呤尿排泄的第一（最低），第二，第三和第四（最高）四分位数的调整后夜间收缩压分别为110.3、107.3、107.3和105.1 mm Hg（P趋势<0.05）。通常未发现尿排泄与舒张压相关，可可碱排泄与血压无关。抗高血压治疗，糖尿病和饮酒改变了咖啡因尿排泄与收缩压的关系。动态收缩压与咖啡因和其他咖啡因代谢产物的尿排泄呈负相关。我们的结果与咖啡因对血压的潜在保护作用相吻合。

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