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首页> 外文期刊>Human Reproduction >Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study.
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Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study.

机译：血清N端前B型脑钠尿肽水平在多囊卵巢综合征女性心脏壁压力检测中的诊断潜力：一项横断面比较研究。

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BACKGROUND: In addition to the negative effect on fertility, polycystic ovary syndrome (PCOS) has been associated with cardiac pathology. Brain natriuretic peptide (BNP) is a possible marker for cardiac risk, therefore we investigated whether N-terminal pro-B-type BNP (NT-proBNP) increases in women with PCOS compared with healthy women of comparable age and body mass index. METHODS: Thirty women with PCOS and 30 healthy women not suffering from overt cardiac disease were involved in the study. Fasting insulin and serum NT-proBNP levels were measured, and M-Mode echocardiography was performed. Insulin resistance was calculated using the homeostasis model assessment insulin resistance index (HOMA-IR). RESULTS: PCOS subjects had higher NT-proBNP levels than the control subjects (P < 0.001). Abnormal echocardiography indices were detected in 14 of the PCOS subjects (but none of the controls), including valvular heart disease in nine, diastolic dysfunction in two, right ventricular enlargement in one, rightatrial enlargement in one and pulmonary hypertension in one. PCOS subjects (n = 30) showed an increased left ventricular mass (LVM) (P < 0.001) and left ventricular posterior wall thickness (LVPWT) (P = 0.006). In addition, NT-proBNP concentration was positively correlated with LVM (r = 0.587, P = 0.001) and negatively correlated with sex-hormone-binding globulin (r = -0.528, P = 0.003). There was a positive correlation between LVM and HOMA-IR (r = 0.295, P = 0.03) while LVPWT was positively correlated with fasting insulin and HOMA-IR (r = 0.335, P = 0.031 and r = 0.346, P = 0.045, respectively) in PCOS subjects (n = 30). CONCLUSION: The present study demonstrated that the level of NT-proBNP was increased in PCOS subjects with asymptomatic heart disease.
机译：背景：除了对生育的负面影响外，多囊卵巢综合征（PCOS）还与心脏病理学相关。脑钠肽（BNP）是发生心脏病风险的可能标志物，因此与具有相同年龄和体重指数的健康女性相比，PCOS女性的N端前B型BNP（NT-proBNP）是否升高。方法：30名PCOS妇女和30名未患有明显心脏疾病的健康妇女参与了这项研究。测量空腹胰岛素和血清NT-proBNP水平，并进行M型超声心动图检查。使用稳态模型评估胰岛素抵抗指数（HOMA-IR）计算胰岛素抵抗。结果：PCOS受试者的NT-proBNP水平高于对照组（P <0.001）。在14例PCOS受试者中发现了异常的超声心动图指标（但没有对照组），其中包括9例患有瓣膜性心脏病，2例舒张功能不全，1例右心室增大，1例右心房增大和1例肺动脉高压。 PCOS受试者（n = 30）显示左心室质量（LVM）增加（P <0.001）和左心室后壁厚度（LVPWT）（P = 0.006）。此外，NT-proBNP浓度与LVM正相关（r = 0.587，P = 0.001），与性激素结合球蛋白负相关（r = -0.528，P = 0.003）。 LVM和HOMA-IR之间存在正相关（r = 0.295，P = 0.03），而LVPWT与空腹胰岛素和HOMA-IR正相关（r = 0.335，P = 0.031和r = 0.346，P = 0.045） ）在PCOS主题中（n = 30）。结论：本研究证明无症状性心脏病的PCOS患者中NT-proBNP水平升高。

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