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首页> 外文期刊>Human Reproduction >Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis.
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Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis.

机译：精子DNA损伤与IVF和ICSI后妊娠流产的风险增加有关：系统评价和荟萃分析。

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BACKGROUND: Sperm DNA damage is common amongst infertile men and may adversely impact natural reproduction, IUI-assisted reproduction and to a lesser degree IVF pregnancy. The aim of this study was to examine the influence of sperm DNA damage on the risk of spontaneous pregnancy loss after IVF and ICSI. METHODS: We conducted a systematic review and meta-analysis of studies on sperm DNA damage and pregnancy loss after an IVF and/or ICSI pregnancy. RESULTS: Two by two tables were constructed and odds ratios (ORs) were derived from 11 estimates of pregnancy loss (five IVF and six ICSI studies from seven reports). These 11 studies involved 1549 cycles of treatment (808 IVF and 741 ICSI cycles) with 640 pregnancies (345 IVF and 295 ICSI) and 122 pregnancy losses. The combined OR of 2.48 (95% CI 1.52, 4.04, P < 0.0001) indicates that sperm DNA damage is predictive of pregnancy loss after IVF and ICSI. CONCLUSIONS: In conclusion, sperm DNA damage is associated with a significantly increased risk of pregnancy loss after IVF and ICSI. These data provide a clinical indication for the evaluation of sperm DNA damage prior to IVF or ICSI and a rationale for further investigating the association between sperm DNA damage and pregnancy loss.
机译：背景：精子DNA损伤在不育男性中很常见，并且可能对自然生殖，IUI辅助生殖以及IVF怀孕程度产生不利影响。这项研究的目的是检查IVF和ICSI后精子DNA损伤对自然流产的风险的影响。方法：我们对IVF和/或ICSI妊娠后精子DNA损伤和妊娠流失的研究进行了系统的回顾和荟萃分析。结果：建立了两乘两桌的表格，优势比（OR）来自11个估计的妊娠流产（来自七个报告的五个IVF和六个ICSI研究）。这11项研究涉及1549个治疗周期（808个IVF和741个ICSI周期），其中有640例怀孕（345个IVF和295个ICSI）和122例流产。 2.48（95％CI 1.52，4.04，P <0.0001）的组合OR表示，精子DNA损伤可预测IVF和ICSI后的妊娠流产。结论：总之，IVF和ICSI后，精子DNA损伤与妊娠流产的风险显着增加有关。这些数据为评估IVF或ICSI之前精子DNA损伤提供了临床指征，并为进一步研究精子DNA损伤与妊娠流失之间的联系提供了理论依据。

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