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首页> 外文期刊>Human Reproduction >Seminal anti-Mullerian hormone level is a marker of spermatogenic response during long-term gonadotropin therapy in male hypogonadotropic hypogonadism.
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Seminal anti-Mullerian hormone level is a marker of spermatogenic response during long-term gonadotropin therapy in male hypogonadotropic hypogonadism.

机译：在男性促性腺激素性性腺功能减退症的长期促性腺激素治疗期间，精液抗苗勒氏管激素水平是生精反应的标志。

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BACKGROUND: In adult men, anti-Mullerian hormone (AMH) levels are higher in semen than in serum, but the significance and control of its seminal secretion are still unknown. This study evaluated seminal and serum AMH levels during long-term gonadotropin therapy in men with hypogonadotropic hypogonadism (HH). METHODS: A total of 20 men with never treated prepubertal-onset HH received i.m. hCG to normalize testosterone (T) and induce puberty. Afterwards, 11 of them, requiring fertility, were treated with HCG plus recombinant FSH (rFSH) (75 IU) twice a week, whereas 9 continued to receive hCG alone for 12 months. Before and during therapy, serum AMH, inhibin B and T levels were assessed. Semen samples were also collected during therapy for sperm count and seminal AMH assay. RESULTS: HCG alone decreased basal high serum AMH and stimulated T and inhibin B levels. rFSH plus hCG increased seminal AMH levels, which were consequently significantly higher than with hCG alone, and positively correlated to sperm densities and testicular volumes at 3 and 12 months (P < 0.001). CONCLUSIONS: Our data demonstrate that rFSH, added to hCG, stimulates seminal AMH and spermatogenesis in HH. Thus, seminal AMH levels are under T and FSH control and are closely related to progression of spermatogenesis. Our results also suggest that an early seminal AMH increase may be a marker of good future response to gonadotropin therapy in HH.
机译：背景：在成年男性中，精液中的抗穆勒氏激素（AMH）水平高于血清中的水平，但其精液分泌的意义和控制仍未知。这项研究评估了促性腺激素减低性腺功能减退（HH）男性长期促性腺激素治疗期间的精液和血清AMH水平。方法：共有20名从未接受过青春期前HH治疗的男性接受了I.m治疗。 hCG使睾丸激素（T）正常化并诱导青春期。之后，其中11例需要生育的患者每周接受HCG加重组FSH（rFSH）（75 IU）治疗两次，而9例继续单独接受hCG治疗12个月。在治疗之前和期间，评估血清AMH，抑制素B和T水平。在治疗期间还收集了精液样本用于精子计数和精子AMH测定。结果：单独的HCG降低基础高血清AMH并刺激T和抑制素B水平。 rFSH和hCG增加了精液AMH水平，因此明显高于单独使用hCG，并且在3和12个月时与精子密度和睾丸体积呈正相关（P <0.001）。结论：我们的数据表明，将rFSH添加到hCG中可以刺激HH中的精子AMH和精子发生。因此，精液AMH的水平处于T和FSH的控制之下，并且与精子发生的进程密切相关。我们的研究结果还表明，早期精液AMH的升高可能是HH对促性腺激素治疗未来反应良好的标志。

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