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首页> 外文期刊>Human Reproduction >The use of misoprostol before hysteroscopic surgery in non-pregnant premenopausal women: a randomized comparison of sublingual, oral and vaginal administrations.
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The use of misoprostol before hysteroscopic surgery in non-pregnant premenopausal women: a randomized comparison of sublingual, oral and vaginal administrations.

机译：非孕绝经前妇女宫腔镜手术前米索前列醇的使用：舌下，口服和阴道给药的随机比较。

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BACKGROUND: The aim of the present study was to evaluate the efficacy of misoprostol administered orally, vaginally, or sublingually on cervical ripening before hysteroscopic surgery in premenopausal non-pregnant women. METHODS: Non-pregnant premenopausal women scheduled for operative hysteroscopy (with a 10-mm hysteroscope) were assigned by computerized randomization to receive 400 mg of misoprostol, administered either orally or vaginally 6-8 h prior to surgery or 400 mg sublingually 2-4 h prior to surgery. The primary outcome in this study was the preoperative cervical width as measured by the largest number of Hegar dilators. The time to Hegar number 10 was also recorded along with side effects related to misoprostol and complications during surgery for each group. RESULTS: Patients were randomized to receive sublingual (n = 47), oral (n = 47) or vaginal (n = 47) misoprostol. The three groups were comparable in terms of age, BMI (body mass index), parity, gravidity, history of vaginal delivery, post-operative pathological findings and surgeon type. The preoperative cervical width [sublingual: 7.5 +/- 2.0 mm (8, 3-10); oral: 7.5 +/- 1.9 mm (7, 4-10); vaginal: 7.6 +/- 2.4 mm (8, 1-10)] was statistically similar among the groups. The time to Hegar number 10, side effects and complications during the hysteroscopy were comparable among the three groups. CONCLUSION: A limitation of this study was that the surgeons, but not the patients, were blinded to the test procedures. Nevertheless we found that sublingual, oral and vaginal misoprostol were equally effective for cervical priming before hysteroscopic surgery in premenopausal non-pregnant women.
机译：背景：本研究的目的是评估宫腔镜手术前绝经前非妊娠妇女口服，阴道或舌下施用米索前列醇对宫颈成熟的功效。方法：通过计算机随机分配计划进行宫腔镜手术（使用10毫米宫腔镜）的非妊娠绝经前妇女，以接受400 mg米索前列醇，在手术前6-8 h口服或阴道给药或400 mg舌下2-4给药手术前h。这项研究的主要结果是术前宫颈宽度，由最大数量的Hegar扩张器测量。还记录了到Hegar 10号的时间，以及每组与米索前列醇和手术并发症相关的副作用。结果：患者被随机分为舌下（n = 47），口服（n = 47）或阴道（n = 47）米索前列醇。这三组患者在年龄，BMI（体重指数），胎次，妊娠，阴道分娩史，术后病理发现和外科医生类型方面具有可比性。术前宫颈宽度[舌下：7.5 +/- 2.0 mm（8，3-10）;口腔：7.5 +/- 1.9毫米（7、4-10）;阴道：7.6 +/- 2.4毫米（8，1-10）]在各组之间在统计学上相似。在三组中，达到Hegar编号10的时间，宫腔镜检查期间的副作用和并发症相当。结论：这项研究的局限性在于外科医生而不是患者对测试程序不了解。尽管如此，我们发现在绝经前非妊娠妇女的宫腔镜手术前，舌下，口服和阴道使用米索前列醇对宫颈灌注同样有效。

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