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首页> 外文期刊>Human Reproduction >Pituitary-ovarian axis during lactational amenorrhoea. II. Longitudinal assessment of serum FSH polymorphism before and after recovery of menstrual cycles.
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Pituitary-ovarian axis during lactational amenorrhoea. II. Longitudinal assessment of serum FSH polymorphism before and after recovery of menstrual cycles.

机译：泌乳性闭经期间垂体-卵巢轴。二。月经周期恢复前后血清FSH多态性的纵向评估。

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摘要

BACKGROUND: The association of normal serum levels of immunoassayable gonadotrophins with anovulation during lactational amenorrhoea (LA) has not been fully explained. METHODS: Serum FSH polymorphism was analysed in 10 women during LA between days 60 and 70 post-partum and again, in the mid-follicular phase (MFP), after resuming menstrual cyclicity. FSH microheterogeneity was characterized according to charge, using preparative isoelectric focusing, and according to the inner structure of carbohydrate chains, using lectin chromatography. RESULTS: A significantly higher proportion of FSH charge isoforms isolated below pH 4.10 and a lower proportion of FSH isoforms bearing highly branched oligosaccharides were observed during LA when compared to MFP. Further analysis with higher resolution showed that FSH charge isoforms, isolated in the lower pH range in LA, corresponded to FSH molecules bearing highly branched and biantennary oligosaccharides. FSH isoforms bearing hybrid-type oligosaccharides were onlypresent during LA. The circulating FSH isoform mix was significantly less bioactive in LA than in MFP. LA is characterized by a more acidic mix of FSH isoforms, containing hormone bearing less processed oligosaccharides, with decreased biopotency in comparison with the follicular phase. CONCLUSIONS: This FSH microheterogeneity may be one of the critical factors contributing to incomplete follicular development and anovulation during LA.
机译：背景：免疫性促性腺激素的正常血清水平与哺乳期闭经（LA）期间无排卵的关系尚未完全阐明。方法：分析了10名妇女在产后60至70天之间的LA期间血清FSH多态性，并在恢复月经周期后在卵泡中期（MFP）再次进行了分析。 FSH微异质性是根据电荷，使用制备性等电聚焦以及根据碳水化合物链的内部结构（采用凝集素色谱法）来表征的。结果：与MFP相比，在LA期间观察到分离出的pH低于4.10的FSH电荷同工型显着更高，带有高度分支低聚糖的FSH异构体的比例更低。更高分辨率的进一步分析表明，在洛杉矶的较低pH范围内分离出的FSH电荷同工型对应于带有高度分支和双触角寡糖的FSH分子。带有杂合型寡糖的FSH同工型仅在LA期间存在。循环中的FSH同工型混合物在LA中的生物活性明显低于在MFP中。 LA的特征是FSH同工型的酸性更高，其含有荷尔蒙的加工寡糖较少，与卵泡期相比，其生物效能降低。结论：FSH的微异质性可能是导致LA期间卵泡发育和无排卵不完全的关键因素之一。

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