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首页> 外文期刊>Human Reproduction >Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis.
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Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis.

机译：接受胞浆内精子注射和植入前遗传学诊断的强直性肌营养不良患者的实际和预期分娩率。

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BACKGROUND: This study aimed to analyse the reproductive outcome of a large cohort of myotonic dystrophy type 1 (DM1) patients undergoing ICSI and PGD. The secondary outcome parameter of this study was ovarian response as a way to express gonadal function in female DM1 patients. METHODS: Prospective cohort study. Real and expected cumulative delivery rates are descriptive. The reproductive outcome per cycle was compared with that of a control group of patients with X-linked recessive disorders. The comparative analysis of ovarian stimulation parameters in the study group versus the control group was carried out using both bivariate (crude) and multivariate (linear regression) analysis. RESULTS: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The real cumulative delivery rate (max 6 cycles) overall was 46%. The expected overall cumulative delivery rate was 72%. Multivariate analysis did not show a significant difference in total dose of gonadotrophins used for ovarian stimulation between Group A (in which the female partner was affected) and a control group. CONCLUSIONS: This study shows that ICSI and PGD for DM1 offer good reproductive outcome, both in cumulative terms and per treatment cycle. There is no evidence of impaired gonadal function in female DM1 patients.
机译：背景：本研究旨在分析接受ICSI和PGD治疗的一大批强直性肌营养不良1型（DM1）患者的生殖结局。这项研究的次要结果参数是卵巢反应，作为女性DM1患者表达性腺功能的一种方法。方法：前瞻性队列研究。实际和预期的累计交付率具有描述性。将每个周期的生殖结果与X连锁隐性疾病的对照组进行比较。研究组与对照组的卵巢刺激参数比较分析使用双变量（粗）和多元（线性回归）分析进行。结果：1995年至2005年之间，对78对夫妇中的DM1进行了205个ICSI和PGD循环。整体的实际累计输送率（最多6个周期）为46％。预期整体累计交付率为72％。多变量分析未显示在A组（女性伴侣受到影响）和对照组之间用于卵巢刺激的促性腺激素总剂量之间没有显着差异。结论：这项研究表明DM1的ICSI和PGD在累积量和每个治疗周期上均具有良好的生殖效果。没有证据表明女性DM1患者的性腺功能受损。

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