...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Human Reproduction >Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka.
【24h】

Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka.

机译：在斯里兰卡的僧伽罗族人口中，Y染色体微缺失与自发性反复妊娠流产无关。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Many advances have been made in reproductive medicine, yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in approximately 7% of men with low sperm counts and, compared with the general population, a higher frequency of spontaneous pregnancy loss occurs in infertile couples. The current study was designed to examine whether Y chromosome microdeletions were associated with RPL in a Sinhalese population in Sri Lanka. METHODS: The subjects were 76 male partners of couples where the female partner had experienced three or more RPLs. One hundred and twenty random males from the general population were also analysed as a control group. DNA extracted from peripheral blood was tested for Y chromosome microdeletions in the azoospermic factor (AZF), AZFa, AZFb, AZFc regions using a multiplex PCR amplification system. Partial deletions within the AZFc region were also tested. RESULTS: None of the men (76 with RPL, and the 120 controls) had any microdeletions in the AZFa, AZFb, AZFc regions or partial deletions in the AZFc region. CONCLUSIONS: Y chromosome microdeletions do not appear to be important in the aetiology of RPL in this population in Sri Lanka.
机译：背景：生殖医学已取得许多进步，但自然流产仍然是妊娠最常见的并发症。自发性反复妊娠流产（RPL）的病因是多因素的。 Y染色体微缺失在大约7％精子数量少的男性中发现，与普通人群相比，不育夫妇发生自发性妊娠的频率更高。当前的研究旨在检查斯里兰卡Sinhalese人群中Y染色体微缺失是否与RPL相关。方法：受试者为夫妻的76名男性伴侣，其中女性伴侣经历了3个或更多RPL。还分析了来自一般人群的120名随机男性作为对照组。使用多重PCR扩增系统测试从外周血中提取的DNA在无精子因子（AZF），AZFa，AZFb，AZFc中的Y染色体微缺失。还测试了AZFc区域内的部分缺失。结果：无一例男性（76例有RPL，120例对照）在AZFa，AZFb，AZFc区没有微缺失或在AZFc区有部分缺失。结论：在该人群中，Y染色体微缺失在RPL的病因学中似乎并不重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号