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首页> 外文期刊>Human and Experimental Toxicology >Studies on hypoglycaemic effects of polyherbal preparation in streptozotocin-induced diabetic male albino rats
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Studies on hypoglycaemic effects of polyherbal preparation in streptozotocin-induced diabetic male albino rats

机译：多草药制剂对链脲佐菌素诱导的糖尿病雄性白化病大鼠降血糖作用的研究

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Many traditional treatments have been recommended in the alternative system of medicine for diabetes mellitus. However, the mode of action of most of the herbals used has not been defined. It has been reported that sex hormones are important regulators of insulin-mediated events in skeletal muscles. In view of this, a novel herbal preparation containing antidiabetic and aphrodisiac plants was used in the present study. Adult male albino rats were divided into following groups after induction of diabetes. Rats were given an intraperitoneal (i.p.) injection of streptozotocin (STZ), at a dose of 65 mg/kg body weight after overnight fasting, to induce diabetic state with blood glucose levels >250 mg/dL. Group 1??"Control rats treated with single i.p. injection of vehicle, Group 2??"Rats treated with polyherbal preparation (PHP; 500 mg/kg body weight by oral intubation, morning and evening for 30 days), Group 3??"STZ-diabetic rats treated orally with equal volumes of vehicle (water) alone and Group 4??"STZ- diabetic rats treated with PHP after 10 days of diabetic induction. STZ-diabetes decreased the body weight, serum insulin level and glucose oxidation in liver and skeletal muscles but increased the fasting blood glucose level. After polyherbal treatment, body weight and glucose oxidation were completely restored to control level while serum insulin level was restored partially and the glucose tolerance was significantly improved. There was a significant decrease in total haemoglobin (Hb) level of diabetic rats when compared to control but polyherbal treatment significantly improved the same. However, the other parameters studied (red blood cell [RBC], white blood corpuscle [WBC], packed cell volume [PCV], mean corpuscular volume [MCV] and mean corpuscular haemoglobin [MCH]) were unaltered. In conclusion, the anti-diabetic properties of PHP appear to be mediated through pancreatic 2-cell regeneration, resulting in maintenance of optimal blood glucose and its oxidation in liver and skeletal muscles.
机译：在糖尿病的替代药物系统中，已经推荐了许多传统疗法。但是，尚未定义大多数所用草药的作用方式。据报道，性激素是骨骼肌中胰岛素介导的事件的重要调节剂。鉴于此，在本研究中使用了包含抗糖尿病和壮阳药植物的新型草药制剂。成年雄性白化病大鼠在诱发糖尿病后分为以下几组。过夜禁食后以65 mg / kg体重的剂量给大鼠腹膜内（i.p.）注射链脲佐菌素（STZ），以诱导糖尿病状态，血糖水平> 250 mg / dL。第1组“用单次ip注射媒介物治疗的对照大鼠，第2组”用多草药制剂（PHP;早，晚30天经口插管500 mg / kg体重）治疗的大鼠，第3组。糖尿病诱导10天后，“单独用等体积的媒介物（水）口服治疗的STZ-糖尿病大鼠和第4组的STZ-糖尿病大鼠用PHP治疗”。 STZ糖尿病降低了体重，血清胰岛素水平和肝脏和骨骼肌的葡萄糖氧化，但增加了空腹血糖水平。经多草药治疗后，体重和葡萄糖氧化完全恢复至对照水平，而血清胰岛素水平则部分恢复，葡萄糖耐量得到明显改善。与对照组相比，糖尿病大鼠的总血红蛋白（Hb）水平显着降低，但是多草药治疗显着改善了糖尿病。但是，其他研究参数（红细胞[RBC]，白血球[WBC]，堆积细胞体积[PCV]，平均红细胞体积[MCV]和平均红细胞血红蛋白[MCH]）不变。总之，PHP的抗糖尿病特性似乎是通过胰腺2细胞再生来介导的，从而维持了最佳血糖及其在肝脏和骨骼肌中的氧化。

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