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首页> 外文期刊>Human and Experimental Toxicology >Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats
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Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats

机译：幽门螺杆菌树皮提取物对链脲佐菌素诱导的白化病大鼠糖原和碳水化合物代谢的改变的衰减

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摘要

The present study was undertaken to assess the effect of Helicteres isora L. on four important enzymes of carbohydrate metabolism (glucokinase [GK], hexokinase [HK] phosphofructokinase [PFK] and fructose-1, 6-bisphosphatase [FBP]) along with glycogen content of insulin-dependent (skeletal muscle and liver) and insulin-independent tissues (kidneys and brain) in streptozotocin (STZ; 60 mg/kg)-induced model of diabetes for 30 days. Administration of bark extracts (100, 200 mg/kg) for 30 days led to decrease in plasma glucose levels by approximately 9.60% and 22.04% and 19.18% and 33.93% on 15th and 30th day, respectively, of the experiment. Liver and two-kidney weight expressed as percentage of body weight significantly increased in diabetics (P < 0.05) versus normal controls. Renal glycogen content increased by 10 folds while hepatic and skeletal muscle glycogen content decreased by 75% and 68% in diabetic controls versus controls. H. isora did not affect glycogen content in any tissue. The decreased activities of PFK, GK, FBP and HK in diabetic controls were 40%, 50%, 50% and 60% and bark extract of H. isora partially corrected this alteration. The efficacy of the bark extract was comparable with Tolbutamide, a well-known hypoglycemic drug.
机译：进行本研究以评估螺旋藻对碳水化合物代谢的四种重要酶（葡萄糖激酶[GK]，己糖激酶[HK]磷酸果糖激酶[PFK]和果糖-1、6-双磷酸酶[FBP]）以及糖原的影响链脲佐菌素（STZ; 60 mg / kg）诱导的糖尿病模型中胰岛素依赖性（骨骼肌和肝脏）和胰岛素非依赖性组织（肾脏和大脑）的含量持续30天。给予树皮提取物（100、200 mg / kg）30天后，在实验的第15天和第30天分别使血浆葡萄糖水平分别降低了约9.60％，22.04％，19.18％和33.93％。与正常对照组相比，糖尿病患者的肝脏和两肾重量以体重百分比表示明显增加（P <0.05）。与对照组相比，糖尿病对照组的肾脏糖原含量增加了10倍，而肝脏和骨骼肌的糖原含量减少了75％和68％。 H. isora不影响任何组织中的糖原含量。在糖尿病对照组中，PFK，GK，FBP和HK的活性降低了40％，50％，50％和60％，而鸢尾的树皮提取物部分纠正了这种改变。树皮提取物的功效与众所周知的降血糖药甲苯磺丁酰胺相当。

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