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首页> 外文期刊>Human and Experimental Toxicology >Environmental lead exposure and its relationship to traffic density among Senegalese children: a pilot study.
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Environmental lead exposure and its relationship to traffic density among Senegalese children: a pilot study.

机译：塞内加尔儿童中环境铅的暴露及其与交通密度的关系：一项试点研究。

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In Senegal, as in many developing countries, traffic density is increasing in urban areas; in Dakar more than 50% of vehicles use gasoline. Yet the extent and real magnitude of the problem has neither been recognized nor assessed in these countries. Systemic data assessment of lead pollution and people's exposure are not well known in Senegal. This study was also designed to determine the impregnation levels of the lead released by the exhaust of cars and the changes of some early biological markers in Senegalese children. Blood lead (BPb) levels showed that all the children enrolled were exposed. However, lead exposure levels (from 34.7 to 145.8 microg/L) were less important for children living in rural areas (60.9+/-18.3 microg/L) than for those living in urban areas (106.7+/-16.9 microg/L). These changes could be correlated to the difference in the automobile traffic between both these regions (P < 0.001). BPb mean levels found in boys were higher than those in girls (P < 0.05). Despite elevated BPblevels, all values for blood zinc protoporphyrin and urine delta-aminolevulinic acid were within physiological ranges. In addition, variations in some biological markers of oxidative stress and renal disorders were seen; however, they must be confirmed by a future epidemiological study.
机译：在塞内加尔，就像许多发展中国家一样，城市地区的交通密度正在增加。在达喀尔，超过50％的车辆使用汽油。但是，这些国家尚未认识到或未评估问题的严重程度和实质。塞内加尔尚不了解铅污染和人们暴露的系统数据评估。这项研究还旨在确定塞内加尔儿童中汽车尾气释放铅的浸渍水平以及某些早期生物学标记的变化。血铅（BPb）水平表明所有入选的儿童都已暴露。然而，铅的暴露水平（从34.7微克/升至145.8微克/升）对生活在农村地区的儿童（60.9 +/- 18.3微克/升）的重要性不如城市儿童（106.7 +/- 16.9微克/升） 。这些变化可能与这两个区域之间的汽车流量差异相关（P <0.001）。男孩的BPb平均水平高于女孩（P <0.05）。尽管BPb水平升高，但血锌原卟啉和尿液中的δ-氨基乙酰丙酸的所有值均在生理范围内。此外，还发现了氧化应激和肾脏疾病的某些生物学指标的变化。但是，必须通过未来的流行病学研究予以证实。

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