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首页> 外文期刊>Human and Experimental Toxicology >Protective role of curcumin on colchicine-induced cognitive dysfunction and oxidative stress in rats
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Protective role of curcumin on colchicine-induced cognitive dysfunction and oxidative stress in rats

机译：姜黄素对秋水仙碱诱导的认知功能障碍和氧化应激的保护作用

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摘要

Dementia is a syndrome of progressive nature, affects wide range of cognitive abilities like memory, language, calculation and so on, neuropsychiatric and social deficits to impair the routine social functions. The present study was designed to assess the effect of curcumin against colchicine-induced cognitive dysfunction and oxidative stress in rats and compare it with rivastigmine. Colchicine (15 μg/5μl) was administered to male Wistar rats intracerebroventricularly (i.c.v.) by stereotaxic apparatus to induce cognitive dysfunction. Administration of colchicine caused poor retention of memory in elevated plus maze, passive avoidance apparatus and Morris water maze paradigms. Chronic treatment with curcumin (100, 200 and 400 mg/kg, p.o.) twice daily and rivastigmine (2.5 mg/kg, p.o.) daily for a period of 28 days beginning 7 days prior to colchicine injection significantly improved colchicine-induced cognitive impairment. Biochemical assessment revealed that i.c.v. colchicine injection significantly increased lipid peroxidation, depleted reduced glutathione levels and decreased acetyl cholinesterase (AChE) activity in rat brains. Chronic administration of curcumin significantly reduced the elevated lipid peroxidation, restored the reduced glutathione levels and AChE activity; however, rivastigmine failed to prevent oxidative stress. The results of the current study indicate that curcumin (100, 200 and 400 mg/kg, p.o.) twice daily has a protective role against colchicine-induced cognitive impairment and associated oxidative stress.
机译：痴呆症是一种进行性综合症，会影响广泛的认知能力，例如记忆，语言，计算等，神经精神病和社交缺陷会损害常规的社交功能。本研究旨在评估姜黄素对秋水仙碱诱导的大鼠认知功能障碍和氧化应激的作用，并将其与卡巴拉汀进行比较。通过立体定位仪向脑室内（i.c.v.）对雄性Wistar大鼠腹膜内施用秋水仙碱（15μg/5μl）以诱导认知功能障碍。在高架迷宫，被动回避装置和莫里斯水迷宫范式中，秋水仙碱的施用导致记忆力差。从秋水仙碱注射前的7天开始，每天两次姜黄素（100、200和400 mg / kg，p.o.）慢性治疗，每天使用rivastigmine（2.5 mg / kg，p.o.）进行28天的慢性治疗，可显着改善秋水仙碱诱导的认知障碍。生化评估显示i.c.v.秋水仙碱注射液可显着增加大鼠脂质过氧化，减少谷胱甘肽水平降低和乙酰胆碱酯酶（AChE）活性降低。长期给予姜黄素可显着降低脂质过氧化反应的升高，恢复降低的谷胱甘肽水平和AChE活性。但是，卡巴拉汀不能阻止氧化应激。当前研究的结果表明，姜黄素（每天两次，分别为100、200和400 mg / kg）对秋水仙碱引起的认知障碍和相关的氧化应激具有保护作用。

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