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Hepatoprotective effects of selenium during diabetes in rats

机译：硒对大鼠糖尿病的肝保护作用

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The present study investigated the hepatoprotective role of selenium during alloxan-induced diabetes in rats. Male Wistar rats were divided into four groups, namely, normal control, selenium treated, diabetic, and selenium-treated diabetic. Diabetes was induced in the animals by injecting alloxan intraperitoneally at a dose rate of 150 mg/kg body weight. Selenium in the form of sodium selenite was supplemented to rats at a dose level of 1 ppm in drinking water, ad libitum for two time durations of 2 and 4 weeks. The effects of different treatments were studied on various parameters in rat liver, which included serum glucose levels, serum insulin levels, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid per oxidation (LPO), glutathione reduced (GSH), oxidized glutathione (GSSG), total glutathione (TG), superoxide dismutase (SOD), catalase (CAT), glutathione reductase, glutathione peroxidase, metallothionein (MT), and histoarchitecture. A significant increase in the serum glucose levels, LPO levels, and in enzyme activities of ALP, ALT, and AST was observed in diabetic rats which, however, got decreased significantly upon supplementation with selenium. On the contrary, decreased enzyme activities of GSSG, SOD, and CAT and depressed levels of GSH as well as serum insulin levels were observed in diabetic rats which got improved following selenium supplementation. Interestingly, MT levels were increased both in diabetic and selenium-treated diabetic rats. Further, marked alterations in histoarchitecture were seen in diabetic rats with the prominent features being congestion in sinusoids, lipid accumulation, and centrilobular hepatocyte degeneration. However, selenium treatment to diabetic rats showed overall improvement in the hepatic histoarchitecture.
机译：本研究调查了硒在四氧嘧啶诱导的糖尿病大鼠中的肝保护作用。将雄性Wistar大鼠分为四组，即正常对照组，硒治疗的，糖尿病的和硒治疗的糖尿病的。通过以150mg / kg体重的剂量腹膜内注射四氧嘧啶在动物中诱发糖尿病。在大鼠中，以1 ppm的剂量水平向大鼠补充亚硒酸钠形式的硒，持续时间为2周和4周。研究了不同治疗方法对大鼠肝脏各种参数的影响，包括血清葡萄糖水平，血清胰岛素水平，碱性磷酸酶（ALP），天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），脂质过氧化脂质（LPO），谷胱甘肽还原型（GSH），氧化型谷胱甘肽（GSSG），总谷胱甘肽（TG），超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽还原酶，谷胱甘肽过氧化物酶，金属硫蛋白（MT）和组织结构。在糖尿病大鼠中观察到血清葡萄糖水平，LPO水平以及ALP，ALT和AST酶活性显着增加，但是在补充硒后显着降低。相反，在糖尿病大鼠中观察到GSSG，SOD和CAT的酶活性降低，GSH水平降低，血清胰岛素水平降低，硒补充后改善。有趣的是，在糖尿病和硒治疗的糖尿病大鼠中，MT水平均升高。此外，在糖尿病大鼠中观察到组织结构的显着改变，其突出特征是正弦曲线充血，脂质蓄积和小叶肝细胞变性。但是，硒对糖尿病大鼠的治疗显示肝脏组织结构的整体改善。

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