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首页> 外文期刊>Human and Experimental Toxicology >Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice
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Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice

机译：初榨椰子油可改善环磷酰胺对小鼠的全身毒性

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Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L, having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties.
机译：初榨椰子油（VCO）是一种未经精制的核仁油，由椰子（Cocos nucifera L）制备，具有重要的营养和药用价值。实验研究表明它具有抗氧化，抗炎，免疫刺激和降血脂作用。本研究评估了其对鼠模型中福尔马林诱导的慢性炎症和环磷酰胺（CTX）诱导的全身毒性的影响。口服VCO可有效减轻福尔马林诱发的小鼠足爪水肿，其功效与双氯芬酸差不多。口服VCO（8 g / kg体重）可以轻微降低CTX诱导的小鼠血尿素，肌酐，硫代巴比妥酸反应性物质（TBARS）和肝标志物酶的升高。在这些动物中，发现肝脏和肾脏的过氧化氢酶，超氧化物歧化酶和谷胱甘肽过氧化物酶活性以及细胞内的谷胱甘肽和TBARS水平得到改善。总体而言，该研究揭示了VCO可能通过其抗氧化剂和抗炎特性来抵抗CTX引起的继发毒性。

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