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首页> 外文期刊>Human and Experimental Toxicology >Chronicity of neurological features in ciguatera fish poisoning.
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Chronicity of neurological features in ciguatera fish poisoning.

机译：慢性鱼类中毒的神经系统特征的慢性。

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A 43-year-old woman complained of colicky abdominal pain, followed by numbness, myalgias, and muscle weakness in the four limbs after eating a grouper (Epinepheius spp.). She presented to our hospital 36 hours later with increased myalgias, muscle weakness, and malaise. On examination, the muscle power and sensation in her four limbs appeared to be normal. She was given an intravenous infusion of mannitol 20% (200 ml over 1 hour) and an intramuscular injection of diclofenac (75 mg). Her myalgias then improved and she was discharged. She presented to our hospital again 1 week later with poor appetite, malaise, numbness of the four limbs, and increased muscle weakness. On examination, the muscle weakness was more marked in the lower limbs (4+/5) than in the upper limbs (5-/5) and proximally than distally. She also had some difficulty in getting up from a squatting position. She was given another intravenous infusion of mannitol 20% (200 ml over 1 hour), following which there was subjectively slight improvement in her muscle weakness. Herplasma creatine phosphokinase level was normal. Electromyography performed 4 weeks later revealed no abnormalities. When she was reviewed 45 days after the consumption of the grouper, her muscle weakness and malaise had improved considerably. She could then stand up from a squatting position. However, mild impairment of finger grip was still present. Chronicity of neurological features in other reported cases (e.g., chronic fatigue, relapse of symptoms after exposure to ciguateric fish or alcohol, and peripheral neuropathy) may also indicate a lengthy persistence of ciguatoxins in the body.
机译：一名43岁的妇女抱怨吃石斑鱼（Epinepheius spp。）后腹部四肢绞痛，四肢麻木，肌痛和肌肉无力。 36小时后，她到我们医院就诊，伴有肌痛，肌无力和不适感增加。经检查，她四肢的肌肉力量和感觉似乎正常。给她静脉注射了20％的甘露醇（200毫升，历时1小时）和肌肉内注射双氯芬酸（75毫克）。然后她的肌痛得到改善，她出院了。 1周后，她再次到我们医院就诊，食欲不振，全身不适，四肢麻木和肌肉无力增加。检查时，下肢（4 + / 5）的肌肉无力比上肢（5- / 5）和近端的肌无力明显。她也很难从下蹲姿势站起来。再次给她静脉滴注20％的甘露醇（1小时内200毫升），此后主观上她的肌肉无力有了轻微的改善。血清肌酸磷酸激酶水平正常。 4周后进行肌电图检查未发现异常。食用石斑鱼后45天接受复查时，她的肌肉无力和不适感得到了明显改善。然后，她可以从蹲下站起来。但是，仍然存在轻度的手指抓握障碍。在其他报道的病例中，神经系统疾病的慢性（例如，慢性疲劳，暴露于白斑鱼或酒后的症状复发以及周围神经病）也可能表明白斑毒素在体内长期存在。

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