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首页> 外文期刊>Human and Experimental Toxicology >Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds.
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Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds.

机译：暴露于Cr（VI）和Cr（V）化合物的小鼠肝脏的比较组织学研究。

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摘要

Chromium toxicity is strongly dependent on its oxidation state. Cr(VI) is carcinogenic and mutagenic, although its in vivo and in vitro toxic effects are related to its intracellular fate. Inside the cells, Cr(VI) is rapidly reduced to stable Cr(III). As Cr(V) and Cr(IV) species have been reported to be formed in the Cr(VI) reduction pathways, Cr(VI)-induced damage is thought, at least in part, to arise from these hypervalent species. The study of Cr(VI) reduction mechanisms and the characterization of the effects of each reactive intermediate constitute important steps towards a better understanding of chromium toxicity. The purpose of this work is to enlarge the scope of Cr(VI)-induced alterations in mouse to other chromium species. Our studies have led to the in situ preparation of a new Cr(V) complex, 1Cr(V)-BT](2-), a stable compound at neutral pH, which mimics Cr(VI) reduction intermediates. The effect of Cr(V) on the histology of mice liver is assessed and compared with similar Cr(VI) assays. Liver toxicity was examined after single administrations of Cr(VI) or [Cr(V)-BT](2-) to mice. Both compounds produced reversible hepatic damage in a time-dependent manner. However, Cr(V) toxic effects have proved to be more rapid than with Cr(VI), permitting the role of Cr(VI) intermediates formed during intracellular chromium reduction to be highlighted.
机译：铬的毒性在很大程度上取决于其氧化态。 Cr（VI）具有致癌性和致突变性，尽管其体内和体外毒性作用与其细胞内命运有关。在电池内部，Cr（VI）迅速还原为稳定的Cr（III）。据报道，由于Cr（VI）和Cr（IV）物种在Cr（VI）还原途径中形成，因此Cr（VI）诱导的损害被认为至少部分是由这些高价物种引起的。 Cr（VI）还原机理的研究和每种活性中间体的作用表征是迈向更好地了解铬毒性的重要步骤。这项工作的目的是扩大Cr（VI）诱导的小鼠对其他铬物种的改变的范围。我们的研究导致原位制备新的Cr（V）配合物1Cr（V）-BT]（2-），这是一种在中性pH下稳定的化合物，可模拟Cr（VI）还原中间体。评估Cr（V）对小鼠肝脏组织学的影响，并将其与类似的Cr（VI）分析进行比较。对小鼠单次施用Cr（VI）或[Cr（V）-BT]（2-）后检查肝毒性。两种化合物均以时间依赖性方式产生可逆性肝损伤。但是，已证明Cr（V）的毒性作用比Cr（VI）更快，这使得在细胞内铬还原过程中形成的Cr（VI）中间体的作用得以突出。

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