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Hormesis: the new approach in risk assessment?

机译：增效：风险评估的新方法？

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摘要

Hormesis is a dose-response phenomenon characterized by either a U-shaped or an inverted U-shaped dose response depending on the different end points measured. In a paper in this issue of the journal, Drs Jayjock and Lewis advocate for the application of hormesis in the field of industrial hygiene, and suggest the use of hormesis as a default assumption in the risk assessment process. However, there are many difficulties for the utilization of hormesis in the field of industrial hygiene. Indeed, it is impossible to test the hormesis hypothesis in many commonly employed experimental model systems for end points of public health concern, and the mechanism of low-dose stimulation of hormesis is not clear. Even if hormesis were proven biologically, its assessment is limited due to difficulties of study design, biological markers selection, statistical power considerations, model and end point selection, and risk model approaches.
机译：兴奋剂是一种剂量反应现象，其特征是根据所测量的不同终点呈U型或倒U型剂量反应。 Jayjock博士和Lewis博士在该期杂志的一篇论文中主张在工业卫生领域中使用增效剂，并建议将增效剂作为风险评估过程中的默认假设。但是，在工业卫生领域，利用药效存在许多困难。的确，不可能在许多常用的实验模型系统中针对公共卫生问题的终点来检验兴奋剂假说，而且低剂量刺激兴奋剂的机理尚不清楚。即使对兴奋剂进行了生物学证明，但由于研究设计，生物标志物选择，统计功效，模型和终点选择以及风险模型方法的困难，其评估仍然受到限制。

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