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首页> 外文期刊>Magnetic resonance imaging clinics of North America >New contrast agents for imaging the liver.
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New contrast agents for imaging the liver.

机译:用于肝脏成像的新型造影剂。

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摘要

The contrast agents suited for hepatic imaging can be divided into nonspecific, extracellular space- (ECS) directed, reticuloendothelial system- (RES) selective, and hepatocyte-selective compounds. There is a wide variation in regard to biodistribution, pharmacokinetics, contrast behavior, and tissue specificity. The ECS contrast agents provide information on vascularization and perfusion similar to that of X-ray contrast agents. The RES- and hepatocyte-specific contrast agents offer more "functional" information that may enhance tissue characterization; however, the biology of the different hepatocellular and nonhepatocellular tumors is limiting the diagnostic efficacy of the tissue-specific compounds in many respects.
机译:适用于肝脏成像的造影剂可分为非特异性,细胞外空间-(ECS)定向,网状内皮系统-(RES)选择性和肝细胞选择性化合物。在生物分布,药代动力学,对比行为和组织特异性方面存在很大差异。 ECS造影剂可提供与X射线造影剂类似的血管生成和灌注信息。 RES和肝细胞特异性造影剂提供了更多的“功能”信息,可以增强组织特征。然而,不同肝细胞和非肝细胞肿瘤的生物学在许多方面限制了组织特异性化合物的诊断效力。

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