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首页> 外文期刊>Zeitschrift fur Anorganische und Allgemeine Chemie >Comparative study of three mononuclear vanadium-aromatic 1,2-diol complexes: Structure, characterization and anti-proliferating effects against cancer cells
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Comparative study of three mononuclear vanadium-aromatic 1,2-diol complexes: Structure, characterization and anti-proliferating effects against cancer cells

机译：三种单核钒-芳族1,2-二醇配合物的比较研究：对癌细胞的结构，表征和抗增殖作用

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摘要

Three mononuclear vanadium complexes containing aromatic 1,2-diols (catechol and naphthalene-2, 3-diol) ligands,[V ~(IV)O(cat) _2][1, 3-HPDA] 2·CH _3OH (1), [V ~(IV)O(N-2, 3-D) _2][1, 3-H _2PDA] (2), and [V ~VO _2(N-2, 3-D)(1, 3-HPDA)]·1, 3-PDA (3) (cat = catechol, N-2, 3-D = naphthalene-2, 3-diol, 1, 3-PDA = 1, 3-propanediamine) were synthesized and characterized by X-ray diffraction, IR and UV/Vis spectroscopy, and cyclovoltammetry. X-ray analysis reveals that the spatial frameworks of complexes 1-3 are all constructed by hydrogen bonds donated by [1, 3-H nPDA] ~(n+) (n = 1, 2) cation, forming distinct chain structures. Complexes 1 and 2 are both in the non-chiral form of VO(L) _2, but 2 crystallizes in the chiral space group (P6 _522), due to the symmetry element of spiral axis, whereas complex 3 contains both enantiomers of chiral VO _2(L _1)(L _2) units, but crystallizes in the non-chiral space group (P 1). The electrochemical behavior of the three complexes is studied in comparison with that of the free ligands. Complex 1 shows a pair of potentials assigned to the redox behavior of vanadium, while complexes 2 and 3 exhibit no such redox potentials. Pharmaceutical screening of complexes 1-3 were carried out against three representative cancer cell lines: A-549 (lung cancer), Bel-7402 (liver cancer) and HCT (colonic cancer) by MTT [3-(4, 5-dimethylthiazoyl-2-yl)-2, 5-diphenyltetrazolium bromide] assay. The results show that the vanadium-catechol complex 1 exhibits more obvious anti-proliferating effects against the three cell-lines, whereas the two vanadium-N-2, 3-D complexes 2 and 3 basically display no such effects.
机译：三种含有芳族1,2-二醇（邻苯二酚和萘-2，3-二醇）配体[[V〜（IV）O（cat）_2] [1，3-HPDA] 2·CH _3OH的单核钒配合物（1） ，[V〜（IV）O（N-2，3-D）_2] [1，3-H _2PDA]（2）和[V〜VO _2（N-2，3-D）（1，3 -HPDA）]·1、3-PDA（3）（cat =儿茶酚，N-2、3-D =萘-2、3-二醇，1，3-PDA = 1，3-丙二胺）合成并表征通过X射线衍射，IR和UV / Vis光谱以及循环伏安法进行分析。 X射线分析表明，配合物1-3的空间框架全部由[1，3-H nPDA]〜（n +）（n = 1，2）阳离子提供的氢键构成，形成独特的链结构。配合物1和2均为非手性形式的VO（L）_2，但由于螺旋轴的对称性，2在手性空间群中结晶（P6 _522），而配合物3包含手性VO的两种对映体_2（L _1）（L _2）个单位，但在非手性空间群（P 1）中结晶。比较了三种配合物与游离配体的电化学行为。配合物1显示出一对分配给钒的氧化还原行为的电位，而配合物2和3未显示出这种氧化还原电位。通过MTT [3-（4，5-dimethylthiazoyl--）对三种代表性癌细胞系：A-549（肺癌），Bel-7402（肝癌）和HCT（结肠癌）进行了复合物1-3的药物筛选。 [2-yl）-2，5-二苯基溴化四溴化铵]测定法。结果显示钒-邻苯二酚配合物1对三种细胞系表现出更明显的抗增殖作用，而两种钒-N-2、3-D配合物2和3基本上没有这种作用。

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