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首页> 外文期刊>HIV medicine >Hazardous drinking is associated with an elevated aspartate aminotransferase to platelet ratio index in an urban HIV-infected clinical cohort.
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Hazardous drinking is associated with an elevated aspartate aminotransferase to platelet ratio index in an urban HIV-infected clinical cohort.

机译：在城市感染HIV的临床人群中，有害饮酒与天冬氨酸转氨酶与血小板比率指数升高相关。

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OBJECTIVES: The aim of the study was to determine the relationship between alcohol consumption and liver fibrosis as assessed by aspartate aminotransferase to platelet ratio index (APRI) in HIV-infected adults and to explore the relative contributions of alcohol and hepatitis C virus (HCV) to APRI among HIV/HCV-coinfected adults. METHODS: We performed a cross-sectional analysis of data from an observational clinical cohort. Alcohol consumption was categorized according to National Institute on Alcohol Abuse and Alcoholism guidelines. We defined significant liver disease as APRI>1.5, and used multinomial logistic regression to identify correlates of increased APRI. RESULTS: Among 1358 participants, 10.4% reported hazardous drinking. It was found that 11.6% had APRI>1.5, indicating liver fibrosis. Hazardous drinking was associated with increased APRI [adjusted relative risk ratio (RRR) 2.30; 95% confidence interval (CI) 1.26-4.17]. Other factors associated with increased APRI were male gender, viral hepatitis, and HIV transmission category of injecting drug use. Among coinfected individuals, 18.3% had APRI>1.5, and hazardous drinking was not associated with APRI. Among non-HCV-infected individuals, 5.3% had APRI>1.5 and hazardous drinking was associated with increased APRI (adjusted RRR 3.72; 95% CI 1.40-9.87). CONCLUSIONS: Hazardous drinking is an important modifiable risk factor for liver fibrosis, particularly among non-HCV-infected patients. Clinicians and researchers must address alcohol use as the burden of liver disease increases among HIV-positive individuals.
机译：目的：本研究的目的是确定艾滋病毒感染成年人中天门冬氨酸转氨酶与血小板比率指数（APRI）评估的酒精摄入与肝纤维化之间的关系，并探讨酒精与丙型肝炎病毒（HCV）的相对贡献HIV / HCV合并感染的成年人中APRI下降。方法：我们对来自观察性临床队列的数据进行了横断面分析。根据国家酒精滥用和酒精中毒指南，对酒精消费进行了分类。我们将重大肝病定义为APRI> 1.5，并使用多项逻辑回归分析来确定APRI增加的相关性。结果：在1358名参与者中，有10.4％的人报告了有害饮酒。发现11.6％的APRI> 1.5，表明肝纤维化。危险饮酒与APRI升高有关[调整后的相对危险度（RRR）2.30; 95％置信区间（CI）1.26-4.17]。与APRI增加有关的其他因素是男性，病毒性肝炎和注射毒品的HIV传播类别。在合并感染的个体中，有18.3％的APRI> 1.5，并且危险饮酒与APRI没有关系。在未感染HCV的个体中，有5.3％的APRI> 1.5，危险饮酒与APRI升高有关（调整后的RRR 3.72; 95％CI 1.40-9.87）。结论：危险饮酒是肝纤维化的重要可调整危险因素，尤其是在非HCV感染患者中。临床医生和研究人员必须解决饮酒问题，因为艾滋病毒阳性患者的肝脏疾病负担增加。

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