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首页> 外文期刊>Zoonoses and Public Health >Neotropical Bats from Costa Rica harbour Diverse Coronaviruses
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Neotropical Bats from Costa Rica harbour Diverse Coronaviruses

机译：哥斯达黎加的新热带蝙蝠带有多种冠状病毒

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摘要

Bats are hosts of diverse coronaviruses (CoVs) known to potentially cross the host-species barrier. For analysing coronavirus diversity in a bat species-rich country, a total of 421 anal swabs/faecal samples from Costa Rican bats were screened for CoV RNA-dependent RNA polymerase (RdRp) gene sequences by a pancoronavirus PCR. Six families, 24 genera and 41 species of bats were analysed. The detection rate for CoV was 1%. Individuals (n=4) from four different species of frugivorous (Artibeus jamaicensis, Carollia perspicillata and Carollia castanea) and nectivorous (Glossophaga soricina) bats were positive for coronavirus-derived nucleic acids. Analysis of 440 nt. RdRp sequences allocated all Costa Rican bat CoVs to the -CoV group. Several CoVs sequences clustered near previously described CoVs from the same species of bat, but were phylogenetically distant from the human CoV sequences identified to date, suggesting no recent spillover events. The Glossophaga soricina CoV sequence is sufficiently dissimilar (26% homology to the closest known bat CoVs) to represent a unique coronavirus not clustering near other CoVs found in the same bat species so far, implying an even higher CoV diversity than previously suspected.
机译：蝙蝠是多种冠状病毒（CoV）的宿主，已知它们可能会越过宿主物种的屏障。为了在蝙蝠物种丰富的国家/地区分析冠状病毒的多样性，通过泛冠状病毒PCR筛选了总共421个来自哥斯达黎加蝙蝠的肛门拭子/粪便样品中CoV RNA依赖的RNA聚合酶（RdRp）基因序列。分析了六个科，24属和41种蝙蝠。 CoV的检出率为1％。来自四种不同食食性（Artibeus jamaicensis，Carollia perspicillata和Carollia castanea）和肉食性（Glossophaga soricina）蝙蝠的个体（n = 4）对冠状病毒来源的核酸呈阳性。分析440 nt。 RdRp序列将所有哥斯达黎加蝙蝠CoV分配给-CoV组。几个CoV序列聚集在同一物种的蝙蝠的先前描述的CoV附近，但与迄今为止确定的人类CoV序列在系统发育上距离较远，这表明最近没有发生溢出事件。 Glossophaga soricina CoV序列足够不同（与最接近的已知蝙蝠CoV有26％的同源性），代表一种独特的冠状病毒，没有聚类到目前为止在同一蝙蝠物种中发现的其他CoV附近，这意味着CoV多样性比以前怀疑的还要高。

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