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首页> 外文期刊>Zoological Science >Vitamin A insufficiency accelerates the decrease in the number of sperminduced by an environmental disruptor, bisphenol A, in neonatal mice
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Vitamin A insufficiency accelerates the decrease in the number of sperminduced by an environmental disruptor, bisphenol A, in neonatal mice

机译：维生素A功能不足会加速环境破坏剂双酚A诱导的新生小鼠精子数量减少

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摘要

Exposure of neonatal mice to an estrogenic endocrine disruptor, bisphenol A, resulted in a malfunction of the testes when the animals became adults. The effect of bisphenol A was cancelled out by concurrent administration of retinol acetate, a naturally occurring metabolite of vitamin A. In contrast, the effect of endocrine disruption became more severe in mice neonatally exposed to bisphenol A and nursed by mothers fed a vitamin A-deficient diet only a few days before and after parturition. These results clearly show that maternal vitamin A is important for relieving in a baby the effect of endocrine disruption caused by environmental xenoestrogens, and suggest that the changes in the content of vitamin A and similar physiological factors in the habitat may be worth considering in studies on environmental disruptors.
机译：新生小鼠暴露于雌激素内分泌干扰物双酚A时，成年动物会导致睾丸功能异常。同时给予维生素A的天然代谢产物视黄醇乙酸酯可抵消双酚A的作用。相反，新生双酚A并由喂食维生素A-的母亲哺乳的小鼠对内分泌的破坏作用更为严重。分娩前后仅几天缺乏饮食。这些结果清楚地表明，母体维生素A对于缓解婴儿由环境异雌激素引起的内分泌干扰的影响很重要，并表明在栖息地研究中维生素A含量和类似生理因素的变化可能值得考虑。环境破坏者。

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