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首页> 外文期刊>Zoological Science >Manipulation of the somatosensory cortex modulates stimulus-induced repetitive ear movements in a seizure-sensitive strain of gerbil.
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Manipulation of the somatosensory cortex modulates stimulus-induced repetitive ear movements in a seizure-sensitive strain of gerbil.

机译：操纵体感皮层可调节对癫痫敏感的沙鼠品系中刺激诱导的重复性耳部运动。

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摘要

Some Mongolian gerbils (Meriones unguiculatus) respond to stimulation by seizures, the pattern of which changes progressively during development. We previously established a seizure-sensitive strain, MGS/ldr, in which all animals exhibit such stimulus-induced seizures. We have now noted that all adults of this strain also show repetitive backward movements of the ears at the beginning of stimulus-induced seizures, although the incidence varies with the individual. We examined whether the cerebral cortex was involved in these movements and found that electrical stimulation of an area of the somatosensory cortex elicited strong backward movement of the ear on the contralateral side, and that unilateral application of bicuculline, a GABA(A) receptor antagonist, induced spontaneous repetitive backward movements of the same ear. In this area, sharp waves appeared in the electrocortigram during the repetitive ear movements induced by seizure-inducing stimuli. Unilateral ablation of this area abolished stimulus-induced repetitive movements of the contralateral ear, but had no effects on those of the ipsilateral ear. These results suggest that, in certain types of seizure-susceptible subjects, it may be possible to modify stimulus-induced repetitive movements by manipulating a certain area of the somatosensory cortex which is related to these movements and that this gerbil strain may be useful in research on this subject.
机译：一些蒙古沙鼠（Meriones unguiculatus）对癫痫发作的刺激做出反应，癫痫发作的模式在发育过程中会逐渐变化。我们先前建立了癫痫发作敏感株MGS / ldr，其中所有动物均表现出这种刺激诱发的癫痫发作。现在我们已经注意到，该菌株的所有成年人在刺激诱发的癫痫发作开始时也表现出耳朵的反复向后运动，尽管发病率因人而异。我们检查了大脑皮层是否参与了这些运动，发现对体感皮层区域的电刺激会引起对侧的耳朵强烈向后运动，以及单侧应用Gcuculline（一种GABA（A）受体拮抗剂），引起同一只耳朵的自发性重复向后运动。在该区域中，在癫痫发作刺激引起的重复性耳部运动期间，心电图中出现了尖锐的波。该区域的单侧消融消除了刺激引起的对侧耳朵的重复运动，但对同侧耳朵没有影响。这些结果表明，在某些类型的易患癫痫发作的受试者中，可能有可能通过操纵与这些运动相关的体感皮层的某个区域来修改刺激诱发的重复性运动，并且这种沙鼠菌株可能在研究中有用关于这个问题。

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