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首页> 外文期刊>Zoological Science >Altered mechanical properties in smooth muscle of mice with a mutated calponin locus
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Altered mechanical properties in smooth muscle of mice with a mutated calponin locus

机译：钙蛋白突变的小鼠平滑肌机械特性的改变

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The mechanical properties of smooth muscles in aorta and vas deferens were studied in mice with a mutated basic calponin locus to learn the physiological function of calponin. The intact smooth muscles were stimulated with high KCl and the force development was compared between calponin deficient (knockout, KO) mice and wild type (WT) ones. The isometric force induced by various concentrations of high KCl was lower in KO than in WT both in aorta and in vas deferens. The length-force relations were compared between KO and WT The active isometric force in KO was significantly lower at most muscle lengths examined than in WT without the change in resting force both in aorta and in vas deferens. In vas deferens, the rate of force development after quick release in length at the peak force was significantly faster in KO than in WT. The above results show that the force development is lower and the rate of cross-bridge cycle is faster in KO mice than in WT ones, suggesting that calponin plays basic roles in the control of the contraction of smooth muscle. [References: 29]
机译：在具有突变的基本钙钙蛋白基因座的小鼠中研究了主动脉和输精管中平滑肌的机械特性，以了解钙蛋白的生理功能。用高氯化钾刺激完整的平滑肌，并比较钙蛋白缺乏（敲除，KO）小鼠和野生型（WT）小鼠的力量发展。在主动脉和输精管中，各种浓度的高KCl诱导的等轴测力在KO中均低于WT。比较了KO和WT的长度力关系。在检查的大多数肌肉长度上，KO的主动等距力均显着低于WT，而在主动脉和输精管中静息力均无变化。在输精管中，在峰值力处快速释放长度后的力量发展速度在KO中显着快于WT。以上结果表明，与野生型小鼠相比，KO小鼠的力量发展更低，跨桥循环的速度更快，这表明钙蛋白在控制平滑肌收缩中起着基本作用。 [参考：29]

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