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首页> 外文期刊>Zoological Science >The Novel Mutant scl of the Medaka Fish, Oryzias latipes, Shows No Secondary Sex Characters.
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The Novel Mutant scl of the Medaka Fish, Oryzias latipes, Shows No Secondary Sex Characters.

机译：Medaka鱼的新颖突变体，Oryzias latipes，未显示第二性征。

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摘要

A new mutant that has neither male nor female secondary sex characters was found in the medaka, Oryzias latipes. Both XX and XY mature mutants had gonads with many spermatozoa, but spawning did not occur when the mutants were paired with normal males or normal females. F1 progeny were successfully obtained by artificial insemination using unfertilized eggs from wild-type females and spermatozoa of the XY mutant. The mutant phenotype did not occur in the F1 progeny from this cross. Incrossing among the F1 progeny produced 17 mutant offspring out of 68 progeny (25%), demonstrating that the mutant phenotype is caused by a single recessive mutation. This mutant was named scl (sex character-less). Because papillary processes, a male secondary sex character, were induced in the XY mutants by androgen administration, it seems that the androgen receptor is functioning normally. We found a loss-of-function type mutation in the P450c17 gene of the mutant; this gene encodes a steroidogenic enzyme required for the production of estrogen and androgen. The scl phenotype was completely linked to the mutant genotype of P450c17, strongly suggesting that mutation at the P450c17 locus is responsible for the scl mutant phenotype.
机译：在青aka（Oryzias latipes）中发现了一个既没有男性也没有女性第二性特征的新突变体。 XX和XY成熟突变体都有很多精子的性腺，但是当突变体与正常雄性或正常雌性配对时，不会产卵。通过使用未受精卵从野生型雌性和XY突变体的精子中人工授精成功地获得了F1后代。该杂交的F1后代中未出现突变表型。 F1后代之间的杂交产生了68个后代中的17个突变后代（25％），表明该突变表型是由单个隐性突变引起的。这个突变体被命名为scl（无性别特征）。由于雄激素的施用在XY突变体中诱导出了乳头状突起，这是男性的第二性征，因此雄激素受体似乎功能正常。我们在该突变体的P450c17基因中发现了功能丧失型突变。该基因编码产生雌激素和雄激素所需的类固醇生成酶。 scl表型与P450c17的突变基因型完全相关，强烈暗示P450c17基因座处的突变是scl突变表型的原因。

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