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首页> 外文期刊>Zoological Science >Localization of ovarian inhibin/activin subunits in follicular dominanceduring the estrous cycle of guinea pigs
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Localization of ovarian inhibin/activin subunits in follicular dominanceduring the estrous cycle of guinea pigs

机译：豚鼠发情周期卵泡优势中卵巢抑制素/激活素亚基的定位

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The cellular localization of inhibin alpha, beta (A) and beta (B) subunits in cyclic ovaries of the guinea pig was investigated. The immunoreactivity of inhibin alpha, beta (A) and beta (B) subunits was localized to the granulosa cells of some large healthy follicles in each ovary throughout the estrous cycle. The number of follicles that stained was in accordance with the number of offspring typical in guinea pigs. Inhibin beta (B) was also localized to the granulosa cells of smalt antral follicles on Day 4. There were two kinds of staining patterns for inhibin alpha, beta (A) and beta (B) subunits on Day 12. strongly stained follicles identical to those observed on Days 8 and 16, and weakly stained follicles that showed atresia in hematoxylin and eosin (HE) stained sections. Two types of ovarian cysts were found throughout the estrous cycle in this experiment: serous cysts and follicular cysts. The incidence of serous cysts and follicular cysts were 64% and 24% of animals, respectively. There was no positive reaction for inhibin alpha, beta (A) and beta (B) subunits in the corpora lutea, other follicles or any kind of ovarian cyst during the estrous cycle. These results comfirm that only dominant follicles stain positively for inhibin alpha and beta (A) subunits and are in agreement with the phenomenon that the follicular development of guinea pigs shows two waves of growth. This study is also the first to describe the ovarian cysts during the estrous cycle in guinea pigs systematically.
机译：研究了豚鼠环状卵巢中抑制素α，β（A）和β（B）亚基的细胞定位。在整个发情周期中，抑制素α，β（A）和β（B）亚基的免疫反应性位于每个卵巢中一些大型健康卵泡的颗粒细胞中。染色的卵泡数量与豚鼠中典型的后代数量一致。在第4天，抑制素β（B）也定位于smalt窦卵泡的颗粒细胞。在第12天，抑制素α有两种染色模式，即β（A）和β（B）亚基。在第8和16天观察到的卵泡和苏木精和曙红（HE）染色切片中显示闭锁的微弱卵泡。在该实验的整个发情周期中发现了两种类型的卵巢囊肿：浆液性囊肿和滤泡性囊肿。浆液性囊肿和滤泡性囊肿的发生率分别为动物的64％和24％。在发情周期中，黄体，其他卵泡或任何类型的卵巢囊肿中抑制素α，β（A）和β（B）亚基均无阳性反应。这些结果证实只有抑制性卵泡对抑制素α和β（A）亚基染色呈阳性，并且与豚鼠的卵泡发育显示出两波生长的现象一致。这项研究也是首次系统性描述豚鼠发情周期卵巢囊肿的方法。

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