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首页> 外文期刊>Zoological Science >Relative potency of three homologous natriuretic peptides (ANP, CNP and VNP) in eel osmoregulation.
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Relative potency of three homologous natriuretic peptides (ANP, CNP and VNP) in eel osmoregulation.

机译：三种同种利尿钠肽（ANP，CNP和VNP）在鳗鱼渗透调节中的相对效能。

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Evidence has accumulated that atrial natriuretic peptide (ANP) plays important roles in seawater adaptation in eels. However, the roles of the other two natriuretic peptides (CNP and VNP) in osmoregulation have not been examined yet. In the present study, the effects of homologous ANP, CNP and VNP were compared on plasma Na+ concentration (an indicator of plasma osmolality), hematocrit (an approximate indicator of blood volume) and drinking rate in freshwater- and seawater-adapted eels. In seawater eels, ANP and VNP, but not CNP, infused at 5 pmol/kg/min decreased plasma Na+ concentration and drinking rate and increased hematocrit. In freshwater eels, ANP and VNP failed to decrease plasma Na+ concentration but increased hematocrit to the same extent as in seawater eels. Inhibition of drinking was not detectable in freshwater eels because of little drinking before NP infusions. These results show that the effects of NPs on plasma Na+ concentration, drinking rate and hematocrit are mediated by NPR-A, since only ANP and VNP that bind with higher affinity to NPR-A are effective in seawater eels. The mechanisms of regulation of plasma Na' concentration and hematocrit are unknown, but NPR-A is present in the responsible tissues for regulation of hematocrit in both freshwater and seawater eels. However, NPR-A may be absent in the tissues of freshwater eels that are responsible for regulation of plasma Na' concentration.
机译：已有证据表明心房利钠肽（ANP）在鳗鱼的海水适应中起重要作用。但是，尚未检查其他两种利尿钠肽（CNP和VNP）在渗透调节中的作用。在本研究中，比较了同源ANP，CNP和VNP对淡水和海水适应的鳗鱼血浆Na +浓度（血浆渗透压的指标），血细胞比容（近似血容量的指标）和饮水速率的影响。在海水鳗鱼中，以5 pmol / kg / min的剂量注入ANP和VNP，但未注入CNP会降低血浆Na +浓度和饮水速率，并增加血细胞比容。在淡水鳗鱼中，ANP和VNP未能降低血浆Na +浓度，但使血细胞比容升高的程度与海水鳗鱼相同。在淡水鳗鱼中未检测到饮酒抑制作用，因为在NP注入前很少饮酒。这些结果表明，NPs对血浆Na +浓度，饮水速率和血细胞比容的影响是由NPR-A介导的，因为只有与NPR-A具有更高亲和力的ANP和VNP在海水鳗中才有效。血浆Na'浓度和血细胞比容的调节机制尚不清楚，但NPR-A存在于负责调节淡水和海水鳗鱼血细胞比容的负责组织中。然而，负责调节血浆Na'浓度的淡水鳗鱼组织中可能不存在NPR-A。

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