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首页> 外文期刊>Zoological Science >Expression patterns of smad family members during embryogenesis of theascidian Halocynthia roretzi
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Expression patterns of smad family members during embryogenesis of theascidian Halocynthia roretzi

机译：中华绒螯蟹胚胎发生过程中Smad家族成员的表达模式

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The ascidian embryo has been long thought to show a mosaic mode of development. However, recent studies revealed significance of cell-cell communication during cleavage stages of embryogenesis. FGF and BMP signalings play critical roles in determination of cell types. Little is, however, known about regulation of competence of cells to the signals. Here we report the isolation of ascidian smad genes; Hrsmad4 which encodes a homolog of smad4 of vertebrates, Hrsmad6/7 which encodes a homologous gene of smad 6 and smad7 of vertebrates, and Hrsmad2/3 which encodes a homolog of smad2 and smad3 of vertebrates. The mRNAs of the isolated smad family genes were maternally inherited in egg and early embryos. While Hrsmad4 and Hrsmad6/7 RNAs distributed broadly in the early embryos, Hrsmad2/3 RNA was preferentially accumulated in the animal hemisphere.
机译：人们长期以来一直认为海鞘胚胎显示出镶嵌的发育模式。但是，最近的研究揭示了胚胎发生分裂阶段细胞间通讯的重要性。 FGF和BMP信号传导在确定细胞类型中起关键作用。然而，关于细胞对信号能力的调节知之甚少。在这里，我们报告了海鞘smad基因的分离。 Hrsmad4编码脊椎动物smad4的同源物，Hrsmad6 / 7编码脊椎动物的smad 6和smad7的同源基因，Hrsmad2 / 3编码脊椎动物的smad2和smad3的同源物。分离的smad家族基因的mRNA在卵和早期胚胎中是母系遗传的。尽管Hrsmad4和Hrsmad6 / 7 RNA广泛分布在早期胚胎中，但Hrsmad2 / 3 RNA却优先在动物半球中积累。

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