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首页> 外文期刊>Zoological Science >Detection of Elevated Antibody Against Calreticulin by ELISA in Aged Cynomolgus Monkey Plasma
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Detection of Elevated Antibody Against Calreticulin by ELISA in Aged Cynomolgus Monkey Plasma

机译：ELISA法检测食蟹猴血浆中钙网蛋白的抗体

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摘要

Calreticulin (Crt) is a molecular chaperone ubiquitously present in the endoplasmic reticulum. In non-human primates, age-related occurrence of anti-Crt antibody has not been reported. We developed an ELISA assay for an anti-Crt antibody and determined the age-related increase in the levels of anti-Crt antibody in three groups of cynomolgus monkeys: juvenile (1.5 yr), young adults (5--10 yr) and aged adults (20--34 yr). Mean plus or minus plus or minus SD auto-antibody levels at 450 nm in juvenile, young adults and aged groups were 0.23 plus or minus plus or minus 0.18, 0.30 plus or minus plus or minus 0.28, and 0.55 plus or minus plus or minus 0.33, respectively. Statistically significant differences were noted in the autoantibody levels to Crt among the aged group and juvenile or young adults. This is the first report to demonstrate the expression of anti-Crt autoantibody in aged monkeys and indicates that cynomologous monkeys may serve as an appropriate nonhuman primate model for studies of age-related alteration of immune function in elderly humans. Though preliminary, this finding merits further investigation to determine the relationship between immunosenescence and expression of antibodies to Crt.
机译：钙网蛋白（Crt）是普遍存在于内质网中的分子伴侣。在非人类的灵长类动物中，尚未报道抗Crt抗体与年龄相关的现象。我们开发了一种抗Crt抗体的ELISA分析方法，并确定了三组食蟹猴的抗Crt抗体水平与年龄相关的增加：幼年（1.5岁），成年成年人（5--10岁）和年龄较大的猕猴成人（20--34岁）。青少年，年轻人和老年组在450 nm处的平均正负负SD自身抗体水平为0.23正负正负0.18、0.30正负正负0.28和0.55正负正负。 0.33。在老年组和青少年中，Crt自身抗体水平存在统计学上的显着差异。这是第一个证明抗Crt自身抗体在衰老猴子中表达的报告，并表明食蟹猴可能是研究老年人与年龄相关的免疫功能变化的合适的非人类灵长类动物模型。尽管是初步的，但该发现值得进一步研究以确定免疫衰老与抗Crt抗体表达之间的关系。

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