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首页> 外文期刊>Zoological Science >Effects of Transient Forebrain Ischemia on the Hippocampus of the Mongolian Gerbil (Meriones unguiculatus): An Immunohistochemical Study
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Effects of Transient Forebrain Ischemia on the Hippocampus of the Mongolian Gerbil (Meriones unguiculatus): An Immunohistochemical Study

机译：短暂性前脑缺血对蒙古沙鼠（Meriones unguiculatus）海马的影响：一项免疫组织化学研究

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摘要

In the Mongolian gerbil, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia and delayed neuronal cell death in the CA1 region of the hippocampus due to their incomplete Circle of Willis. In the present study, the expression of fibroblast growth factor 2 (FGF2), its receptors (FGFR1 and FGFR2), glial fibrillary acidic protein (GFAP), and isolectin B4 (ISLB4) was investigated by immunohistochemical and lectin-binding methods after BCCAO was performed for 5 min in gerbils. One day after BCCAO, the pyramidal cells of the CA1 region of the hippocampus showed degenerative changes and lowered expression of FGF2, FGFR1, and FGFR2. Three days after BCCAO, there was an increase in GFAP-positive astrocytes and ISLB4-positive microglial cells. From five to 10 days after BCCAO, intense neuronal cell death in the stria pyramidale of the hippocampal CA1 region was observed, as well as an increase in GFAP-positive astrocytes and decrease in ISLB4-positive microglial cells. These results indicate that transient forebrain ischemia induces neuronal cell death with lowered expression of FGF2 and its receptors, and that the activation of glial cells may not directly lead to neuronal cell death.
机译：在蒙古沙鼠中，双侧颈总动脉闭塞（BCCAO）持续数分钟，会导致海马CA1区局部缺血并延迟神经元细胞死亡，原因是它们的威利斯环不完整。在本研究中，通过免疫组织化学和凝集素结合方法研究了成纤维细胞生长因子2（FGF2），其受体（FGFR1和FGFR2），神经胶质纤维酸性蛋白（GFAP）和异凝集素B4（ISLB4）的表达。在沙鼠中进行了5分钟。 BCCAO后一天，海马CA1区的锥体细胞显示退行性变化并降低FGF2，FGFR1和FGFR2的表达。 BCCAO后三天，GFAP阳性星形胶质细胞和ISLB4阳性小胶质细胞增加。在BCCAO后的5至10天，观察到海马CA1区锥体层的强烈神经元细胞死亡，以及GFAP阳性星形胶质细胞的增加和ISLB4阳性小胶质细胞的减少。这些结果表明，短暂性前脑缺血可诱导神经元细胞死亡，而FGF2及其受体的表达则降低，并且胶质细胞的活化可能不会直接导致神经元细胞死亡。

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