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首页> 外文期刊>Zoological Science >Double-immunolabeling studies of glucocorticoid receptors inenkephalinergic neurons of the rat spinal cord
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Double-immunolabeling studies of glucocorticoid receptors inenkephalinergic neurons of the rat spinal cord

机译：大鼠脊髓脑啡肽能神经元糖皮质激素受体的双重免疫标记研究

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摘要

Using double-immunolabeling, we attempted to localize the glucocorticoid receptor (GR) and methionine-enkephalin-octapeptide (ENK-8) in the rat spinal cord. The 2nd to 8th cervical segments were analyzed in intact and in colchicine-injected animals. GR immunoreactivity was detected in the nuclei of neurons in all segments, and was most intense in small neurons in the superficial layers (laminae 1-3) of the dorsal horn. Medium-sized neurons in laminae 4-6 and the reticular formation, as well as the large ventral horn neurons, all showed moderate immunoreactivity. Double-immunolabeling revealed that, in all regions examined except the ventral horn, some of the OR-positive neurons were also ENK-8-positive. These findings suggest that enkephalinergic neurons in the spinal cord may be regulated by glucocorticoids, each of which is presumably related to the neuronal antinociceptive mechanism in the dorsal horn.
机译：使用双重免疫标记，我们试图在大鼠脊髓中定位糖皮质激素受体（GR）和蛋氨酸-脑啡肽-八肽（ENK-8）。分析完整和注射秋水仙碱的动物的第2至第8颈段。在所有节段的神经元核中均检测到GR免疫反应性，并且在背角浅层（层1-3）的小神经元中GR免疫反应最强。薄层4-6和网状结构的中型神经元，以及大腹角神经元均显示出中等的免疫反应性。双重免疫标记显示，在所有受检区域中，除了腹角，一些OR阳性神经元也都为ENK-8阳性。这些发现表明，脊髓中的脑啡肽能神经元可能受糖皮质激素的调节，糖皮质激素可能与背角的神经元镇痛机制有关。

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